BACKGROUND The treatment of acute myocardial infarction (AMI) is thought to restore antegrade blood flow in the infarct-related artery (IRA) and minimize ischemic damage to the myocardium as soon as possible. The present study aimed to identify possible clinical predictors for no-reflow in patients with AMI after primary percutaneous coronary intervention (PCI). METHODS A total of 312 consecu...

After cardiac ischaemia, a prolonged decrease of coronary microvascular perfusion often occurs even after flow is restored in an upstream artery. This 'no-reflow' phenomenon worsens patient prognosis. In the brain, after stroke, a similar post-ischaemic 'no-reflow' has been attributed to capillary constriction by contractile pericytes. We now show that occlusion of a rat coronary artery, follow...

Correspondence to: Leonarda Galiuto, MD, PhD, Institute of Cardiology, Catholic University of the Sacred Heart, Policlinico A. Gemelli, Largo A. Gemelli, 8, 00136 Rome, Italy; [email protected] . . . . . . . . . . . . . . . . . . . . . . . E xtensively studied both in the experimental and clinical setting, the no reflow phenomenon is clearly associated with unfavourable clinical outcome an...

Recent evidence shows that circulating granulocytes play an important role in capillary stasis and tissue injury. We investigated two aspects of the problem in a Wiggers hemorrhagic shock model of the rat: the survival rate and the microvascular no-reflow phenomenon. A conventional group of rats with normal blood cells and a neutropenic group of rats pretreated with intraperitoneal antigranuloc...

After several hours of ischemia an incomplete return of blood flow has been reported in brain, kidney, skeletal muscle, and heart. The mechanisms responsible for the no-reflow phenomenon have been unclear, and perivascular edema, platelet or red cell plugs, and interstitial hemorrhage have been implicated. In the present study evidence is provided that leukocyte entrapment in capillaries might ...

Distal protection devices such as FilterWire EX have been widely used in carotid artery stenting, however, the large amount of atherothrombotic debris entrapped in the filter could reduce or stop antegrade flow. We present a case of pseudo-no-reflow phenomenon after postdilatation of the stent in a patient with asymptomatic carotid artery stenosis. After several passes using an Export Aspiratio...

Rapid restoration of thrombolysis in myocardial infarction III case no-reflow during percutaneous coronary intervention is imperative. Application punctured balloon intracoronary injection sodium nitroprusside a prompt, safe and effective method. To investigate the effectiveness via treatment artery main objective study. We retrospectively analyzed 76 patients treated with for no-reflow. All su...

Background Radiofrequency (RF) ablation of myocardial tissue is a clinically acceptable therapy for atrial fibrillation and ventricular tachycardia. LGE-MRI has been used to assess immediately post-ablation RF lesions. It was shown that appearance of acute lesions in LGE-MRI changes with time after contrast injection [1,2]. Dickfeld, et al. [1] studied ventricular RF lesions delivered epicardia...