The effectiveness of nitrofurantoin in suppressing bacterial growth in the urinary tract was evaluated by using two different experimental models. Pyelonephritis was produced in rats by direct inoculation of 10(4)Escherichia coli in the medulla of left kidney. Ascending urinary tract infection was induced by inoculation into the urinary bladder of 10(7)Proteus mirabilis, after a partial cystect...

BACKGROUND Urinary tract infections (UTIs) are very common and have been treated with apparent success with antimicrobials for many years. However, there is a paucity of placebo-controlled clinical trials. AIM To measure the symptomatic and bacteriological short-term effect of nitrofurantoin treatment versus placebo, in the treatment of uncomplicated UTI in adult non-pregnant women. DESIGN ...

A 56-year-old female was referred to the respiratory clinic by her general practitioner with a 3-month history of dyspnoea and cough. She was a non-smoker. Her cough persisted despite several trials of medication, including antibiotics and inhaled bronchodilator and steroid therapy. Her past medical history included cervical cancer in 1997 with vault relapse in 1999, treated by hysterectomy, ch...

Resistance of uropathogenic bacteria to antibiotics is an increasing problem in primary health care. The aim of this study was to evaluate antibacterial susceptibility testing of uropathogenic bacteria when performed in general practice. Urine specimens with a known quantity of typically uropathogenic bacteria were sent to 25 general practices. The predictive values of testing a bacterial strai...

Nitrofurantoin is presently used as an antibacterial agent for the urinary tract of both man and animals. A new, quantitative procedure for the determination of this drug in urine consistsof direct extraction of the nonionized form of the drug by the use of nitromethane, addition of an alkaline reagent to the extract to produce a visible color, and determination of the nitrofurantoin concentrat...

The authors report the case of a female patient who developed chronic eosinophilic pneumonia secondary to long-term use of nitrofurantoin for prophylaxis of recurrent urinary tract infections due to urethral stenosis. On high-resolution computed tomography scans, the pulmonary reaction to nitrofurantoin most commonly manifests as an interstitial-alveolar pattern in both lung bases. However, in ...

We report a case of a female admitted to the emergency department with fever and severe type I acute respiratory failure. After detailed examination, all other potential causes were excluded and the patient was diagnosed with nitrofurantoin-induced acute pulmonary toxicity.