background: clomiphene citrate (cc) is the first line agent used for ovulation induction in patients with polycystic ovarian syndrome (pcos). however, there is marked discrepancy between the ovulation and pregnancy rates achieved, which may be attributed to the undesirable effect of cc on cervical mucus and endometrium. objective: the aim of this study was to evaluate the effect of isosorbid mo...

objective(s):dependence and tolerance to opioid analgesics are major problems limiting their clinical application. a-terpineol is a monoterpenoid alcohol with neuroprotective effects which is found in several medicinal plants such as myrtus communis, laurus nobilis, and stachys byzantina. it has been shown that some of these medicinal plants such as s. byzantina attenuate dependence and toleran...

the aim of this study was to investigate the effects of nigella sativa  (ns) fixed oil in comparison to dexamethasone (dex) on inducible nitric oxide synthase (inos), peripheral blood eosinophils (pbe), allergen specific serum igg1 and interleukins and airway inflammation in a murine model of allergic asthma. thirty-one mice were divided into four groups. group  i (n =  6) served as the control...

background and purpose: during recent years, nitric oxide (no) has been considered as a molecule involved in migraine headaches. this free radical involves in initiation of migraine headaches via no/cgmp signaling pathway and vascular relaxation specially big intracranial arteries. therefore, we studied the effects of aqueous extract of origanum vulgare and melilotus officinalis prescribed in m...

endothelial nitric oxide synthase (enos) produces nitric oxide (no) from l-arginine and is important for the maintenance of cardiovascular homeostasis. congestive heart failure (chf) generally results in increased pulmonary blood flow and if untreated leads to pulmonary hypertension and end stage heart failure. we therefore hypothesized that increased pulmonary flow without changes in pressure ...

conclusions our findings indicate that fenofibrate (ppar-α agonist) is able to prevent dn progression and improve kidney performance during chronic uncontrolled hyperglycemia possibly through increase in no bioavailability of kidney. results fenofibrate did not change the blood glucose of normal or diabetic rats. diabetes increased the proteinuria (82%) and blood creatinine of diabetic rats (4....

PURPOSE Interstitial cystitis is a chronic inflammatory disease of the bladder and luminal nitric oxide has been shown to be increased in the bladder in patients with interstitial cystitis. We analyzed endogenous nitric oxide formation and inducible nitric oxide synthase gene expression in the bladder of patients with interstitial cystitis to obtain further knowledge of the localization of indu...

The nasal decongestants oxymetazoline and xylometazoline are frequently used in the topical treatment of rhinitis and sinusitis. As nitric oxide (NO) is thought to play a role in inflammation of the upper respiratory tract, the aim of this study was to examine the in vitro effects of these compounds on the activity and the expression of NO producing enzymes, including the inducible form of NO s...

BACKGROUND Nasal nitric oxide is present in high concentrations in the upper airway relative to the lower respiratory tract. OBJECTIVE To explore the rate of nitric oxide accumulation in the nonventilated nasal cavity. METHODS In 9 healthy subjects previously trained to close the soft palate, steady-state plateau nitric oxide levels were recorded while air was aspirated through the nasal ai...