In clinical practice, upright tilt testing is frequently used to determine the etiology of syncope by trying to induce vasovagal reactions. The importance of the test is underscored by the fact that before the introduction of the test in 1986 by Kenny et al.,1 often expensive cardiac examinations were performed without resulting in a clear diagnosis. The more frequent use of the “passive” unmed...

Liver first-pass metabolism differs considerably among organic nitrates, but little information exists on the mechanism of denitration of these compounds in hepatic tissue. The metabolism of nitrooxybutyl-esters of flurbiprofen and ferulic-acid, a class of organic nitrates with potential therapeutic implication in variety of different conditions, was investigated in comparison with glyceryl tri...

BACKGROUND There is limited evidence that the use of nitrates in acute decompensated heart failure early after presentation to a hospital can improve clinical outcomes. We aimed to determine whether early nitrate exposure is associated with improved survival in a large retrospective cohort study. METHODS AND RESULTS We examined 11 078 acute decompensated heart failure patients who presented t...

Sperelakis, N: Ca and Sr* movements with contraction of depolarized smooth muscle. Am J Physiol 203: 860-866, 1962 Van Breeman C, Siegel B, Hwang OK: Differences in adrenergic activation of coronary and peripheral arteries (abstr). Fed Proc 37: 416, 1978 Winbury MM: Redistribution of left ventricular blood flow produced by nitroglyceriru Example of integration of the macroand microcirculatdon. ...

This paper presents the spatial and temporal mass concentration variations of major acidic species (chlorides, nitrates and sulphates) in high risk particle fraction PM2..5 in Zagreb air. The sampling was carried out at four measuring sites during the summer of 2002 (June – July) and winter 2002-2003 (November – January). The results show no significant differences in pollutant concentration le...

Nitrates are still widely used in the management of coronary artery disease (CAD) in patients with stable and unstable angina, acute myocardial infarction and congestive heart failure. The therapeutic efficacy of these nitrates is due to peripheral venous and arterial dilation that results in decreased myocardial oxygen consumption. Nitrates also dilate large coronary arteries and collaterals w...

The presence of nitrates and nitrites in food is associated with an increased risk of gastrointestinal cancer and, in infants, methemoglobinemia. Despite the physiologic roles for nitrate and nitrite in vascular and immune function, consideration of food sources of nitrates and nitrites as healthful dietary components has received little attention. Approximately 80% of dietary nitrates are deri...

AIM To measure the intracolonic release of nitric oxide end products (nitrates plus nitrites) and eicosanoids in response to intraluminal irritation with deoxycholic acid (DCA). PATIENTS Seven patients with irritable bowel syndrome. METHODS The left colon was perfused with a solution with or without 3 mM deoxycholic acid. Aspirates were assayed for eicosanoids by specific radioimmuno-assay,...