A 7 year old girl referred for investigation of hypogammaglobulinaemia had hypoalbuminaemia and severe necrotising oesophagitis on oesophagogastroduodenoscopy. Nissen fundoplication resolved all clinical and laboratory abnormalities, but she remains under surveillance because ofhistological findings ofBarrett's oesophagus. Erosive reflux oesophagitis can present with minimal localising symptoms...

Mammary gland-derived nestin+ cell populations can be isolated from human male and female donors Stem Cell Research & Therapy 2013, 4:78 doi:10.1186/scrt229 Anja Richter ([email protected]) Nicole Nissen ([email protected]) Peter Mailänder ([email protected]) Felix Stang ([email protected]) Frank Siemers ([email protected]) Charli Kruse ([email protected]...

OBJECTIVE To investigate the 5-year effect of surgeon experience with laparoscopic Nissen fundoplication (LNF). In 2000, a randomized controlled trial (RCT) was prematurely terminated because LNF for gastroesophageal reflux disease was associated with a higher risk to develop dysphagia than conventional Nissen fundoplication (CNF). Criticism focused on alleged bias caused by the relative lack o...

OBJECTIVE To evaluate the 4-year results following a randomised controlled trial (RCT) comparing open (ONF) and laparoscopic (LNF) Nissen fundoplication in children. BACKGROUND It is assumed that long-term results of ONF and LNF are comparable. No randomised studies have been performed in children. METHODS A follow-up study was performed in children randomised to ONF or LNF (clinicaltrials....

PATIENTS Laparoscopic Nissen fundoplication was undertaken in 200 patients between 1991 and 1994. METHODS Pre-operative assessment included symptom score, endoscopy, manometry, and 24 hour pH monitoring of the oesophagus. Patients were evaluated at three and 12 months after surgery with symptom scoring and 96 patients also underwent 24 hour pH studies at three to six months postoperatively. ...

Of 46 patients who had Nissen fundoplication for proved gastro-oesophageal reflux, 25 were available for follow up after a median of 20 years, 15 had died of unrelated causes, and six could not be traced. All 25 patients in the follow up study were personally interviewed: 21 consented to an endoscopy, 14 to 24 hour recording of oesophageal pH and manometry, and 15 to radionucide transit test. R...