Niosomes are a novel drug delivery system, in which the medication is encapsulated in a vesicle. Niosomes are formations of vesicles by hydrating mixture of cholesterol and nonionic surfactants. Different novel approaches used for delivering these drugs include liposomes,microspheres, nanotechnology, micro emulsions, antibody loaded drug delivery, magnetic microcapsules, implantable pumps and n...

Objective: The primary goal of this study was to develop a topical gel containing tramadol hydrochloride-loaded Niosomes injection technique as the vesicular carrier for site-specific delivery. Methods: niosomes were created by varying ratios nonionic surfactants (Tween 80, Tween 60, 20, Span and 80) cholesterol while keeping drug concentration constant. Results Discussion: Each formulation exa...