Even though compounds of nickel, arsenic, cobalt and cadmium are carcinogenic, their mutagenic potentials are rather weak. In contrast, they exert pronounced comutagenic effects, which may be explained by disturbances of different DNA repair systems. Thus, cobalt, arsenic, nickel and cadmium interfere with base and nucleotide excision repair, even though they affect different steps of the respe...

Helicobacter pylori NikR (HpNikR) is a nickel-dependent transcription factor that regulates multiple genes in the H. pylori pathogen. There are conflicting data regarding the locations of the Ni(II) sites and the role of Ni(II) coordination in DNA recognition. Herein, we report crystal structures of (i) the metal-binding domain (MBD) of HpNikR (3.08 Å) and (ii) a mutant, H74A (2.04 Å), designed...

BACKGROUND The pathogenesis of total joint replacement failure is multifactorial. One hypothesis suggests that corrosion and wear of alloys result in metal ion release, which may then cause sensitization and even implant failure, owing to the acquired immune reactivity. OBJECTIVES To assess cobalt, nickel and chromium(VI) release from, and the metal composition of, failed metal-on-ethylene to...

A simple on-line sonodigestion system was successfully used for breakdown organic nickel complexes in environmental waters acidified with diluted nitric acid prior to flow injection total dissolved nickel preconcentration in a microcolumn containing a chelating resin (Chelite Che with iminodiacetic acid groups) and determination by flame atomic absorption spectrometry. For the determination of ...

The transition metals nickel and cobalt, essential components of many enzymes, are taken up by specific transport systems of several different types. We integrated in silico and in vivo methods for the analysis of various protein families containing both nickel and cobalt transport systems in prokaryotes. For functional annotation of genes, we used two comparative genomic approaches: identifica...

Recently there have been a number of reports suggesting the possible importance of metals in ribonucleic acid. Wacker and Vallee (1) have reported the presence of chromium, iron, manganese, nickel, zinc, and other metals in various ribonucleic acid preparations, and have suggested that “metals may bear a functional relationship to protein synthesis and the transmission of genetic information.” ...

Nickel and cadmium usually enter the environment and water resources through wastewater, released by various industries, and may have adverse effects. The current study employs α–Fe2O3 nanoparticles of 20-40 nm in order to remove nickel and cadmium from the wastewater of Saba Battery Company. Also, it investigates the influence of effective parameters on adsorption process, including pH, contac...

Taking into account the use of Nickel brasses in industry a great number of methods for the determination of Ni have been reported. More, theoretical predictions of free Cd increasing with decreasing salinity have been confirmed using cadmium selective electrodes. The method under proposal, for the determination of nickel ions in brass alloys consists of the following steps: Cu masking with sod...

A simple and new simultaneous fourth derivative spectrophotometric method is proposed for the analysis of a two-component system containing cobalt(II) and nickel(II) without separation using 2-hydroxy-3-methoxy benzaldehyde thiosemicarbazone (HMBATSC) as a chromophoric reagent. The reagent reacts with cobalt(II) and nickel(II) at pH 6.0, forming soluble brown and yellow colored species, respect...