Hydrogen-dissolved water has been suggested to be effective for alleviating the oxidative stress. In the present study, neutral-pH hydrogen-enriched electrolyzed water (NHE-water; dissolved hydrogen: 0.90-1.14 parts per million [ppm]; oxido-reduced potential: -150 approximately -80 mV), which was prepared with a water-electrolysis apparatus equipped with a non-diaphragm cell and a highly compre...

Myocardial stretch induces a biphasic force response: a first abrupt increase followed by a slow force response (SFR), believed to be the in vitro manifestation of the Anrep effect. The SFR is due to an increase in Ca²⁺ transient of unclear mechanism. We proposed that Na⁺/H⁺ exchanger (NHE-1) activation is a key factor in determining the contractile response, but recent reports challenged our f...

Sedum alfredii (Crasulaceae) is the only known Cd-hyperaccumulating species that are not in the Brassica family; the mechanism of Cd hyperaccumulation in this plant is, however, little understood. Here, a combination of radioactive techniques, metabolic inhibitors, and fluorescence imaging was used to contrast Cd uptake and translocation between a hyperaccumulating ecotype (HE) and a non-hypera...

Using multiple scattering theory, we show that the generally accepted expression of transverse resistivity in magnetic systems host skyrmions, given by linear superposition ordinary (OHE), anomalous (AHE) and topological Hall effect (THE), is incomplete must be amended an additional term, "non-collinear" (NHE). Its angular form determined texture, spin-orbit field electrons, underlying crystal ...

In trout hepatocytes, hypertonicity and cytosolic acidification are known to stimulate Na+/H+ exchanger (NHE) activity, which contributes to recovery of cell volume and intracellular pH (pHi), respectively. The present study investigated the signalling mechanisms underlying NHE activation under these conditions. Exposing trout hepatocytes to cariporide, a specific inhibitor of NHE-1, decreased ...

We have previously shown that the beta-adrenergic receptor (beta-AR) stimulates activity of the ubiquitous Na-H exchanger (NHE-1) independently of changes in cAMP accumulation and independently of a cholera toxin-sensitive stimulatory GTP-binding protein (Gs). To further investigate the potential role of a GTP-binding protein in coupling the beta-AR to NHE-1, we have used a recently available n...

Epidermal growth factor (EGF) is predominantly secreted by salivary glands and activates Na(+)/H(+) exchanger-1 (NHE-1), which regulates intracellular pH (pH(i)). We investigated the roles of EGF and NHE-1 in esophageal epithelial defense against acid using human esophageal epithelial cell lines and a rat chronic esophagitis model. Esophageal epithelial cells were incubated with acidified mediu...

Letter to the Editor lower affinity for chloroquine and a reduced transport Is the Putative Chloroquine rate. Moreover, their NHE is in a constitutively activated Resistance Mediator CG2 the state, rendering this protein incapable of importing chlo-roquine since no further activation by chloroquine is possible (Wü nsch et al., 1998). of Plasmodium falciparum? Given that complex polymorphisms wi...

HCO3 TRANSPORTERS and the Na /H exchanger (NHE) contribute in a major way to maintenance of ionic and pH homeostasis in neurons. The study by Xue et al. (17) demonstrates that, in prolonged neuronal hypoxia, inhibition of HCO3 transporters by DIDS is protective and inhibition of NHE by either HOE 643 or T-162559 results in increased cell death. These observations have important implications for...