NF-kappa B plays a key role in the production of cytokines in inflammatory diseases. The effects of a novel T cell-specific NF-kappa B inhibitor, SP100030, were evaluated in cultured Jurkat cells and in murine collagen-induced arthritis (CIA). Chemical libraries were screened for NF-kappa B-inhibitory activity. SP100030, a compound identified in this process, inhibited NF-kappa B activation in ...

Purpose: Activated B-cell diffuse large B-cell lymphoma (ABC-DLBCL) is an aggressive, poorly chemoresponsive lymphoid malignancy characterized by constitutive canonical NF-kB activity that promotes lymphomagenesis and chemotherapy resistance via overexpression of antiapoptotic NF-kB target genes. Inhibition of the canonical NF-kB pathway may therefore have therapeutic relevance in ABCDLBCL. Her...

The human growth hormone (GH) gene family consists of five tandemly arranged and highly related genes, including the chorionic somatomammotropins (CSs), at a single locus on chromosome 17. Despite striking homologies in promoter and flanking DNA sequences, the genes within this locus have different tissue-specific patterns of expression: GH-N is expressed almost exclusively in the somatotrophs ...

move into the nucleus is also carried out by the protea-some but only after prior phosphorylation of I␬B by the South San Francisco, California 94080 2 Ontario Cancer Institute I␬B kinase complex (IKK). The IKK is composed of three subunits: two, IKK␣ and IKK␤, are bona fide kinases, 620 University Avenue Toronto, Ontario M5G 2C1 while the third, IKK␥ (NEMO), has no catalytic activity but plays...

Achieving high−efficiency and stable hydrogen evolution from water splitting is a great challenge. Herein, facilely prepared two−dimenssional self−supported catalytic electrode with excellent stability constructed for large−scale production alkaline simulated seawater. The bifunctional by fast mild one−step of sodium borohydride etching on nickel foam (NF) substrate without adding other additiv...

Asbestos fibers cause persistent induction of the oxidative stress sensitive transcription factors nuclear factor kappa-B (NF-kappa B) and activator protein-1 (AP-1) in mammalian cells. These transcription factors play an important role in the regulation of cellular activity. Lipid peroxidation, mediated by reactive oxygen species, is thought to be a possible mechanism in the pathogenicity of a...

Many patients with Crohn's disease carry mutations in NOD2, a molecule that can both activate and attenuate the pro-inflammatory effects of NF-kappa B. Recent studies implicate NOD2-induced ubiquitination of the NF-kappa B regulator NEMO as a potential means of manipulating the NF-kappa B signal.

The effects of human immunodeficiency virus 1 (HIV-1) infection on cellular differentiation and NF-kappa B DNA binding activity have been investigated in a new model of myeloid differentiation. PLB-985 cells represent a bipotential myelomonoblastic cell population capable of either granulocytic or monocytic differentiation after induction with appropriate inducers. By virtue of the presence of ...