نتایج جستجو برای: neutrophil gelatinase associated lipocalin

تعداد نتایج: 1554424  

2014
Saverio Candido Roberta Maestro Jerry Polesel Alessia Catania Francesca Maira Santo S. Signorelli James A. McCubrey Massimo Libra

Cancer remains one of the major cause of death in the Western world. Although, it has been demonstrated that new therapies can improve the outcome of cancer patients, still many patients relapse after treatment. Therefore, there is a need to identify novel factors involved in cancer development and/or progression. Recently, neutrophil gelatinase-associated lipocalin (NGAL) has been suggested as...

Journal: :Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2014
María Teresa Torres-Salido Josefina Cortés-Hernández Xavier Vidal Anna Pedrosa Miquel Vilardell-Tarrés Josep Ordi-Ros

BACKGROUND One of the challenges of treating patients with lupus nephritis (LN) is to accurately assess disease activity and predict its outcome. Since renal-biopsy cannot be performed routinely, new surrogate biomarkers are needed. METHODS We evaluated neutrophil gelatinase-associated lipocalin (NGAL), to predict renal outcome in LN. Serum and urinary NGAL levels, measured by the enzyme-link...

Journal: :Circulation. Cardiovascular interventions 2015
Cristina Quintavalle Chiara Viviani Anselmi Francesca De Micco Giuseppina Roscigno Gabriella Visconti Bruno Golia Amelia Focaccio Bruno Ricciardelli Enzo Perna Laura Papa Elvira Donnarumma Gerolama Condorelli Carlo Briguori

BACKGROUND Neutrophil gelatinase-associated lipocalin (NGAL) is an early marker of acute kidney injury (AKI). METHODS AND RESULTS Urine NGAL and serum NGAL (sNGAL) were assessed at 2, 6, 24, and 48 hours after contrast media (CM) exposure in 458 high-risk patients (development set). Optimal thresholds in predicting contrast-induced AKI (serum creatinine [sCr] increase ≥0.3 mg/dL at 48 hours a...

2015
Giovanni De Caridi Mafalda Massara Francesco Spinelli Raffaele Grande Lucia Butrico Pierandrea Rende Maurizio Amato Rita Compagna Bruno Amato Stefano de Franciscis Raffaele Serra

The association of an axillary artery aneurysm and an abdominal aortic aneurysm is extremely rare. In this study, we describe this association in a 69 year-old-man. We measured this patient's metalloproteinases (MMPs) and Neutrophil Gelatinase - Associated Lipocalin (NGAL) levels over a three years period before the abdominal aortic aneurysm rupture. We speculate that high serium levels of MMPs...

Journal: :Journal of clinical microbiology 2014
M Reichsoellner R B Raggam J Wagner R Krause M Hoenigl

A multiplexed biomarker bundle consisting of nine different inflammation markers was evaluated regarding their diagnostic and prognostic performances in 159 adult systemic inflammatory response syndrome (SIRS) patients enrolled at the emergency department. Fibronectin, interleukin-8 (IL-8), biotin, and neutrophil gelatinase-associated lipocalin (NGAL) were the most robust markers but were not s...

Journal: :The Biochemical journal 2005
Zhimin Tong Xuli Wu Dmitriy Ovcharenko Jiuxiang Zhu Ching-Shih Chen James P Kehrer

NGAL (human neutrophil gelatinase-associated lipocalin) and its mouse analogue 24p3 are members of the lipocalin family of small secreted proteins. These proteins are up-regulated in a number of pathological conditions, including cancers, and may function as transporters of essential factors. Although previous publications have suggested that 24p3 has pro-apoptotic functions, other data are mor...

Journal: :Mediators of Inflammation 1999
P Jönsson M L Ståhl K Ohlsson

Extracorporeal circulation (ECC) used during cardiac surgery causes activation of several inflammatory systems. These events are not fully understood but are responsible for complications during the immediate postoperative period. Neutrophil gelatinase-associated lipocalin (NGAL), a member of the expanding lipocalin family, has recently been described as an inflammatory protein. In this study, ...

Journal: :The Annals of thoracic surgery 2014
Amber O Molnar Chirag R Parikh Steven G Coca Heather Thiessen-Philbrook Jay L Koyner Michael G Shlipak Mary Lee Myers Amit X Garg

BACKGROUND Acute kidney injury (AKI) is a serious complication of cardiac operations for which there remains no specific therapy. Animal data and several observational studies suggest that statins prevent AKI, but the results are not conclusive, and many studies are retrospective in nature. METHODS We conducted a multicenter prospective cohort study of 625 adult patients undergoing elective c...

Journal: :Blood 1995
N Borregaard M Sehested B S Nielsen H Sengeløv L Kjeldsen

Differentiation and maturation of myeloid cells is characterized by the sequential acquisition of two distinct cytoplasmic granule subsets, azurophil granules and specific granules. We recently showed the existence of a third granule subset, gelatinase granules. To investigate whether appearance of gelatinase granules marks a further step in maturation of myeloid cells beyond the appearance of ...

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