Increased reactivity to stress is observed in patients with schizophrenia spectrum disorders and their healthy siblings in comparison to the general population. Additionally, higher levels of neuroticism, as a proposed psychological measure of stress sensitivity, increasethe risk for schizophrenia. HPA axis dysregulation is one of the possible mechanisms related to the vulnerability-stress mode...

The goals of the current study were to use specific measures of affective lability and neuroticism to examine the nomological network surrounding both constructs and to test the degree to which a measure of general personality can account for variability in affective lability. Using a psychiatric outpatient sample (n=48), we assessed personality disorder (PD) symptoms, personality, and level of...

This article investigates mechanisms through which neuroticism leads to distress in daily life. Neuroticism may lead to distress through exposing people to a greater number of stressful events, through increasing their reactivity to those events, or through a mechanism unrelated to environmental events. This article evaluates the relative importance of these three explanations. Subjects were 33...

TheBig Five personality inventorymeasures personality based on five key traits: neuroticism, extraversion, agreeableness, openness to experience, and conscientiousness [Costa, P. T., Jr., &McCrae, R. R. (1992).Normal personality assessment in clinical practice: TheNEOPersonality Inventory.PsychologicalAssessment 4, 5–13]. There is a growingbodyof evidence indicating that individual differences ...

Neuroticism is the heritable and stable personality trait defined by the tendency to experience negative emotion, be easily stressed, and slow to soothe. Neuroticism poses a risk for poor social and health outcomes that has been identified as a major public health concern. To date, factors that attenuate neuroticism's costs have not been identified. The goal of this work was to test the hypothe...

Recent research and theory has highlighted the dynamic nature of amygdala activation. Rather than simply being sensitive to a few limited stimulus categories, amygdala activation appears to be dependent on the goals of the perceiver. In this study, we extend this line of work by demonstrating that the means by which a person seeks to accomplish a goal also modulates the amygdala response. Speci...

BACKGROUND Low birth weight has been inconsistently associated with risk of developing affective disorders, including major depressive disorder (MDD). To date, studies investigating possible associations between birth weight and bipolar disorder (BD), or personality traits known to predispose to affective disorders such as neuroticism, have not been conducted in large cohorts. AIMS To assess ...

PURPOSE This study aimed to investigate the relationship between neuroticism, hopelessness, and depression among older Korean immigrants. To extend this line of research, this study aimed to examine the effects of neuroticism and hopelessness in predicting depression among older Korean immigrants. METHODS Data for this study came from a survey of 220 first generation Korean immigrants aged 65...

Research chronicling links between a polymorphism in the serotonin-transporter gene (5-HTTLPR) and neuroticism has yielded inconsistent results. One possible explanation for this inconsistency is that any gene-phenotype association is obscured by a gene-X-environment (GXE) interaction. We studied a healthy non-clinical sample (N=118) to determine whether the 5-HTTLPR interacts with current life...

BACKGROUND Recently, the nature of personality disorders and their relationship with normal personality traits has received extensive attention. The five-factor model (FFM) of personality, consisting of the personality traits neuroticism, extraversion, openness to experience, agreeableness, and conscientiousness, is one of the proposed models to conceptualize personality disorders as maladaptiv...