نتایج جستجو برای: neuronal degeneration

تعداد نتایج: 172201  

Journal: :The Journal of clinical investigation 2004
Atsushi Otani Michael Ian Dorrell Karen Kinder Stacey K Moreno Steven Nusinowitz Eyal Banin John Heckenlively Martin Friedlander

Inherited retinal degenerations afflict 1 in 3,500 individuals and are a heterogeneous group of diseases that result in profound vision loss, usually the result of retinal neuronal apoptosis. Atrophic changes in the retinal vasculature are also observed in many of these degenerations. While it is thought that this atrophy is secondary to diminished metabolic demand in the face of retinal degene...

Journal: :Notulae Scientia Biologicae 2023

The study was performed to investigate the possible neuroprotective role of palmatine, a protoberberine alkaloid against aluminum-induced aberration in neurotransmitter levels, excitotoxicity, neuronal inflammation, damage, and degeneration. 100 mg/kg aluminum chloride served as inducing agent administered orally male Wistar albino rats for 42 consecutive days. Animals were divided into four gr...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2008
Dick Jaarsma Eva Teuling Elize D Haasdijk Chris I De Zeeuw Casper C Hoogenraad

Mutations in superoxide dismutase (SOD1) cause amyotrophic lateral sclerosis (ALS), an adult-onset progressive paralytic disease characterized by loss of motor neurons, and cause an ALS-like disease when expressed in mice. Recent data have suggested that motor neuron degeneration results from toxic actions of mutant SOD1 operating in both motor neurons and their neighboring glia, raising the qu...

Hossein Hosseinzadeh, Narges Marefati, Somayeh Nazari,

Many chemicals with broad industrial, pharmaceutical and agricultural application produce a neurotoxic syndrome in humans and experimental animals involving weight loss, skeletal muscle weakness and ataxia. Neurotoxicity is defined as a structural change or a functional alteration of the nervous system resulting from exposure to a chemical, biological or physical agent. Neurotoxicity including ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2002
Richard Nass David H Hall David M Miller Randy D Blakely

Parkinson's disease is a complex neurodegenerative disorder characterized by the death of brain dopamine neurons. In mammals, dopamine neuronal degeneration can be triggered through exposure to neurotoxins accumulated by the presynaptic dopamine transporter (DAT), including 6-hydroxydopamine (6-OHDA) and 1-methyl-4-phenylpyridinium. We have established a system for the pharmacological and genet...

Journal: :ILAR journal 2014
Timothy M Rooney Marc R Freeman

Neurite degeneration is a hallmark feature of nearly all neurodegenerative diseases, occurs after most brain trauma, and is thought to be the underlying cause of functional loss in patients. Understanding the genetic basis of neurite degeneration represents a major challenge in the neuroscience field. If it is possible to define key signaling pathways that promote neurite destruction, their blo...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2015
Ashley M Fortress Eric D Hamlett Elena M Vazey Gary Aston-Jones Wayne A Cass Heather A Boger Ann-Charlotte E Granholm

Designer receptors exclusively activated by designer drugs (DREADDs) are novel and powerful tools to investigate discrete neuronal populations in the brain. We have used DREADDs to stimulate degenerating neurons in a Down syndrome (DS) model, Ts65Dn mice. Individuals with DS develop Alzheimer's disease (AD) neuropathology and have elevated risk for dementia starting in their 30s and 40s. Indivi...

Journal: :Journal of the Association for Research in Otolaryngology 2011

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