I n a prior communication we demonstrated that transection of the optic nerve of the cat with consequent retrograde neuronal degeneration did not lead to alteration of the ipsilateral retinal vasculature. We interpreted this to mean that retinal neuronal degeneration does not, of itself, cause an associated vascular degeneration. In the present study the vasculature of the optic disc region of ...

The brain requires task-dependent interregional coherence of information flow in the anatomically connected neural network. However, it is still unclear how a neuronal group can flexibly select its communication target. In this study, we revealed a hidden routing mechanism on the basis of recurrent connections. Our simulation results based on the spike response model show that recurrent connect...

An understanding of the basic elements of neurotransmission in the brain is an important foundation for any consideration of the clinical use and future development of antidepressants. However, attempts to describe the influences of drugs on brain and neuronal function have become increasingly complex, and it is now clear that neuronal processes are complex molecular events involving multiple c...

An understanding of the basic elements of neurotransmission in the brain is an important foundation for any consideration of the clinical use and future development of antidepressants. However, attempts to describe the influences of drugs on brain and neuronal function have become increasingly complex, and it is now clear that neuronal processes are complex molecular events involving multiple c...

One of the most important problems in neuroscience researches is the understanding what is the communication between the immune system and central nervous system. Proinflammatory factors play an important role in this communication. The dysregulation of proinflammatory factors such as cytokines and chemokines is a central feature in the development of neuroinflammation.one of the important&nbsp...

Extrasynaptic communication between neurons or neurons and glia is mediated by the diffusion of neuroactive substances in the volume of the extracellular space (ECS). The size and irregular geometry of the diffusion channels in the ECS substantially differ not only around individual cells but also in different CNS regions and thus affect and direct the movement of various neuroactive substances...