objective wilson disease (wd) is an inherited copper metabolism dysfunction disease characterized by cirrhosis and cns findings. wilson disease is important because it is fatal if not recognized and treated. our goal of study is to investigate the clinical signs and symptoms, lab results and other relevant matters in our patients in order to obtain a better understanding of this potentially let...

here has recently been a great deal of interest in stem cells and the nervous system, in terms of their potential for deciphering developmental issues as well as their therapeutic potential. In this editorial we will critically appraise the different types of stem cells, their therapeutic implications, and the applications to which they have been put, with the hope that the hype that surround t...

Behçet disease is a multisystem disease of unknown cause in which an inflammatory perivasculitis can arise in almost any tissue (Sakane et al., 1999). Neurologic involvement in Behçet disease was first reported by Knapp in 1941. It represented between 4-49% of manifestations of BD (Haghighi et al., 2005). There is one of the most serious causes of long term morbidity and mortality in Behçet’s D...

on chromosome Xp2 1. Rowland's chapter provides an exciting introduction to what proves to be a disappointing volume. Many of the chapters which review current advances in a particular disease are too brief and not well written. For example, a chapter on the construction of a complete restriction map of human chromosome 19 describes, in less than three pages, the strategy used to accomplish suc...

THERE have been many recent reviews of the neurological complications of Hodgkin's disease (Brit. Med. J., 1965; Hutchinson, Leonard, Maudsley and Yates, 1958; Haynal and Regli, 1964). In most of the reported cases, the diagnosis of Hodgkin's disease was established before the appearance of neurological involvement. In the case reported below the mode of presentation was neurological, and the t...

Clinical and laboratory signs of neurological disease were found in 14 patients many years after partial gastrectomy. Vitamin B(12) deficiency occurred in most patients, but only those three who had signs of subacute combined degeneration of the cord and no osteomalacia responded well to treatment.

Botulinum toxins are among the most potent neurotoxins known to humans. In the past 25 years, botulinum toxin has emerged as both a potential weapon of bioterrorism and as a powerful therapeutic agent, with growing applications in neurological and non-neurological disease. Botulinum toxin is unique in its ability to target peripheral cholinergic neurons, preventing the release of acetylcholine ...