Cerebral malaria is the most severe and rapidly fatal neurological complication of Plasmodium falciparum infection and responsible for more than two million deaths annually. The current therapy is inadequate in terms of reducing mortality or post-treatment symptoms such as neurological and cognitive deficits. The pathophysiology of cerebral malaria is quite complex and offers a variety of targe...

To investigate the incidence and pattern of patients managed for traumatic upper cervical spinal fractures (TUCSFs) in teaching hospitals in China over 13 years.We retrospectively reviewed 351 patients with TUCSF admitted to our teaching hospitals. Incidence rates were calculated with respect to age, gender, etiologies of trauma, anatomical distribution, anatomical classification, American spin...

In 80% of all MS cases, patients suffer from relapsingremitting (RR) MS, which have clearly defined periods of neurological deficits followed by (partial) recovery [1]. In those RRMS patients, 65% of the disease cases gradually evolves into secondary progressive (SP) MS, with progressive permanent neurological deficits. In 20% of all MS cases, patients have a progressive disease course from ons...

A patient is presented who had severe headache and then developed a stuttering course of clinical neurological deficits. Arteriography demonstrated an ipsilateral proximal middle cerebral embolus. With recurrence of symptoms, repeat arteriography showed another, more proximal embolus with areas of distal occlusion. The headache probably occurred when the embolus became lodged in a pain sensitiv...

Despite recent advances in stroke prevention and acute stroke therapy, few treatments exist for reversal of fixed neurological deficits after stroke. Cellular therapy offers the possibility of improving neurological deficits months or even years after stroke. Animal studies provide evidence that such treatment may be effective. Many questions, however, remain unanswered regarding cellular thera...

BACKGROUND Carotid dissection may lead to many different types of neurological deficits, both transient and permanent. CASE DESCRIPTION We present a patient with an isolated central retinal artery occlusion who was found to have an ipsilateral carotid dissection by neck computed tomographic scan, later confirmed by angiography. CONCLUSIONS This is the first reported case of carotid dissecti...

Capillary hemangiomas, hamartomatous proliferation of vascular endothelial cells, are rare in the central nervous system (CNS). Intracranial capillary hemangiomas presenting with reversible behavioral abnormalities and focal neurological deficits have rarely been reported. We report a case of CNS capillary hemangioma presenting with transient focal neurological deficits and behavioral abnormali...

over the last 50 years, significant progress has been made in the surgical repair of thoracoabdominal aortic aneurysms (taaa).   improvements in perioperative care and surgical techniques have resulted in reductions in complication and mortality rates. adjunctive use of distal aortic perfusion and cerebrospinal fluid drainage has been especially helpful, reducing the incidence of neurological d...