Hub-and-spoke (HS) network designs arise in transportation and telecommunications systems, where items must flow among spatially separate nodes and scale economies can be attained through the shared use of high capacity links between hubs. As an alternative for the discrete approach of selecting a subset of the existing nodes as hubs, this paper explores the possibility of their continuous loca...

This paper presents an analytic approach to the pattern stability and evolution problem in morphogenesis. The approach used here is based on the ideas from the gene and neural network theory. We assume that gene networks contain a number of small groups of genes (called hubs) controlling morphogenesis process. Hub genes represent an important element of gene network architecture and their exist...

The functional network topology of the adult human brain has recently begun to be noninvasively mapped using resting-state functional connectivity magnetic resonance imaging and described using mathematical tools originating from graph theory. Previous studies have revealed the existence of disproportionally connected brain regions, so called cortical hubs, which act as information convergence ...

Most people-centric delay tolerant networks have been shown to exhibit power-law behavior. Analysis of the temporal connectivity graph of such networks reveals the existence of hubs, a fraction of the nodes, which are collectively connected to the rest of the nodes. In this paper, we propose a novel forwarding strategy called HubCode, which seeks to use the hubs as message relays. The hubs empl...

HYPOTHESIS Different pharmacotherapies for sensorineural hearing loss (SNHL) are interconnected in metabolic networks with molecular hubs. BACKGROUND Sensorineural hearing loss is the most common sensory deficit worldwide. Dozens of drugs have shown efficacy against SNHL in animal studies and a few in human studies. Analyzing metabolic networks that interconnect these drugs will point to and ...

The protein-protein interaction (PPI) network has a small number of highly connected protein nodes (known as hubs) and many poorly connected nodes. Genome-wide studies show that deletion of a hub protein is more likely to be lethal than deletion of a non-hub protein, a phenomenon known as the centrality-lethality rule. This rule is widely believed to reflect the special importance of hubs in or...

The increasing trend of antibiotic resistance in Acinetobacter drastically limits the range of therapeutic agents required to treat multidrug resistant (MDR) infections. This study focused on analysis of novel Acinetobacter strains using a genomics and systems biology approach. Here we used a network theory method for pathogenic and non-pathogenic Acinetobacter spp. to identify the key regulato...

A comprehensive exploration of common and specific plant responses to biotrophs and necrotrophs is necessary for a better understanding of plant immunity. Here, we compared the Arabidopsis defense responses evoked by the biotrophic fungus Golovinomyces orontii and the necrotrophic fungus Botrytis cinerea through integrative network analysis. Two time-course transcriptional datasets were integra...

Brain networks appear to have few and well localized regions with high functional connectivity density (hubs) for fast integration of neural processing, and their dysfunction could contribute to neuropsychiatric diseases. However the variability in the distribution of these brain hubs is unknown due in part to the overwhelming computational demands associated to their localization. Recently we ...

This paper proposes an architecture for routing Internet protocol (IP) packets directly on optical networks. The use of label switching is assumed in the IP routers, while a new routing architecture is introduced to transport IP packets across an optical backbone network. The architecture is based on a two-tier multiplexing approach, with wavelength division multiplexing (WDM) addressing the nu...