Abstract Natural evolutionary strategies (NES) are a family of gradient-free black-box optimization algorithms. This study illustrates their use for the randomly initialized parameterized quantum circuits (PQCs) in region vanishing gradients. We show that using NES gradient estimator exponential decrease variance can be alleviated. implement two specific approaches, and separable NES, parameter...

Thyroid hormone receptor (TR) is a member of the nuclear receptor superfamily that shuttles between the cytosol and nucleus. The fine balance between nuclear import and export of TR has emerged as a critical control point for modulating thyroid hormone-responsive gene expression; however, sequence motifs of TR that mediate shuttling are not fully defined. Here, we characterized multiple signals...

Background: People with non-epileptic seizures (NES) describe challenging relationships with health professionals, and explain negative interactions as common and expected. Despite these difficulties, little is known about how people with NES experience difficult healthcare encounters. Methods: Using a thematic discourse analysis approach, we analysed the free-text survey responses of 135 peopl...

To improve the safety and reliability of offshore structures subject to wave loading, active vibration control problem is always one significant issues in field ocean engineering. This paper deals with near–optimal a nonlinear energy sink (NES) mechanism. By taking dominant mode structure NES into account, dynamic model steel–jacket loading presented first. Then, using parameter perturbation ap...

Abstract The bistable nonlinear energy sink (NES) shows high efficiency in mitigating vibration through targeted transfer (TET). It performs well low- and high-energy input cases, whereas, for a cubic NES, TET occurs only above certain threshold. In this work, the measure of pumping time is extended to harmonic excitation case by application particular integration assumption. An equivalent poin...

Le lait maternel est reconnu comme aliment idéal pour les nouveau-nés, y compris prématurés, avec des avantages nutritionnels, biologiques, émotionnels et socio-économiques l’enfant la famille. Pour bébés l’allaitement joue un rôle essentiel dans mesure où il associé à une réduction du temps d’hospitalisation divers états cliniques résultant d’une prématurité. Les études indiquent faible taux d...

In the cell nucleus the NS1 protein of influenza A virus inhibits both pre-mRNA splicing and the nuclear export of mRNAs. Both the RNA-binding and effector domains of the protein are required for these nuclear functions. Here we demonstrate that the NS1 protein has a latent nuclear export signal (NES) that is located at the amino end of the effector domain. In uninfected, transfected cells the ...

CRM1 exports proteins that carry a short leucine-rich peptide signal, the nuclear export signal (NES), from the nucleus. Regular NESs must have low affinity for CRM1 to function optimally. We previously generated artificial NESs with higher affinities for CRM1, termed supraphysiological NESs. Here we identify a supraphysiological NES in an endogenous protein, the NS2 protein of parvovirus Minut...

CRM1 is an export receptor mediating rapid nuclear exit of proteins and RNAs to the cytoplasm. CRM1 export cargoes include proteins with a leucine-rich nuclear export signal (NES) that bind directly to CRM1 in a trimeric complex with RanGTP. Using a quantitative CRM1-NES cargo binding assay, significant differences in affinity for CRM1 among natural NESs are demonstrated, suggesting that the st...

Over 170 different mutations in the gene encoding SOD1 all cause amyotrophic lateral sclerosis (ALS). Available studies have been primarily focused on the mechanisms underlying mutant SOD1 cytotoxicity. How cells defend against the cytotoxicity remains largely unknown. Here, we show that misfolding of ALS-linked SOD1 mutants and wild-type (wt) SOD1 exposes a normally buried nuclear export signa...