The aim of this study was to investigate whether NGF could reverse the nerve fiber atrophy exhibited by some neurons in old age. We used quantitative immunohistochemical techniques to investigate how the autonomic nerves that supply different blood vessels are affected by aging. Age changes in the nerve plexus were not widespread but were specific to particular vascular targets. Furthermore, wh...

Differentiated oligodendrocytes express neurite growth inhibitory proteins at a time when these cells are involved in the myelination of recently formed fiber pathways. As the process of myelination follows the completion of neurite outgrowth and is concurrent with the stabilization of fiber numbers in a pathway, we set out to determine whether myelination and fiber tract stability could be cau...

PURPOSE The retinal nerve fiber layer (RNFL) exhibits birefringence that is due to the oriented cylindrical structure of the ganglion cell axons. Possible birefringent structures include axonal membranes, microtubules (MTs), and neurofilaments. MTs are generally assumed to be a major contributor, but this has not been demonstrated. In this study, the MT depolymerizing agent colchicine was used ...

The nerve fiber distribution in the epidermis of the hairless rat skin was studied light microscopically by means of zinc iodide-osmium tetroxide staining. Two different morphological types of free nerve fiber endings could be detected: clusters of relatively thick nerve fibers stretched up through the spinous layer up to the granular layer sending off terminal branches. In addition, many solit...

OF DISSERTATION GROWTH FACTOR DELIVERY FROM FIBRIN MATRICS CONTAINING AFFINITY-BASED DELIVERY SYSTEMS TO TREAT PERIPHERAL NERVE INJURY By Matthew David Wood Doctor of Philosophy in Biomedical Engineering Washington University in St. Louis, 2009 Chairperson: Shelly E. Sakiyama-Elbert, Ph.D. This thesis work sought to develop a biomaterial to further the understanding of affinitybased delivery an...

[1] Benatar M, Hammad M, Doss-Rinev H. Concentric-needle fiber electromyografy for the diagnosis of myasthenia gravis. Muscle Nerve 2006; 34: 163–168 [2] Bischoff C. Bedeutung der Einzelfaser-Elektromyografie für die Diagnostik neuromuskulärer Erkrankungen. Klin Neurophysiol 2000; 31: 136–143 [3] Bischoff C. Einzelfaser-EMG mit konzentrischen Nadelelektrode: eine Alternative in der Diagnositik ...

Conduction of an impulse in the nonmyelinated nerve fiber is treated quantitatively by considering it as a direct consequence of the coexistence of two structurally distinct regions, resting and active, in the fiber. The profile of the electrical potential change induced in the vicinity of the boundary between the two regions is analyzed by using the cable equations. Simple mathematical formula...

Cornea confocal microscopy (CCM) is a novel non-invasive method to detect small nerve fiber pathology. CCM generally correlates with outcomes of skin biopsies in patients with small fiber pathology. The aim of this study was to quantify the morphology of small nerve fibers of the cornea of patients with fibromyalgia in terms of density, length and branching and further phenotype these patients ...

Introduction Small fiber involvement in different patterns of peripheral neuropathy has stirred much interest during the past few years due to the role played by these fibers in pain perception and the availability of new techniques of skin biopsy that permit the study of nerve endings [1]. The use of protein gene product 9.5 (PGP 9.5) as a panaxonal marker in skin biopsies has led to identific...