A prospective study of 110 patients with systemic lupus erythematosus (SLE) was undertaken to evaluate the reliability of clinical signs of lupus nephritis, which developed in 39 (35%) patients. Those patients with SLE who showed no clinical signs of lupus nephritis had an excellent survival rate (10 year survival 93%) and retained normal renal function (serum creatinine less than 130 mumols/l)...

FcγRIIB-/-yaa mice develop severe lupus glomerulonephritis due to lack of an inhibitory immune cell receptor combined with a Y-chromosome linked autoimmune accelerator mutation. In the present study, we have investigated nephritis development and progression in FcγRIIB-/-yaa mice to find shared features with NZB/NZW F1 lupus prone mice and human disease. We sacrificed 25 male FcγRIIB-/-yaa mice...

Immune mediated nephropathy is one of the most serious manifestations of lupus and is characterized by severe inflammation and necrosis that, if untreated, eventually leads to renal failure. Although lupus has a higher incidence in women, both sexes can develop lupus glomerulonephritis; nephritis in men develops earlier and is more severe than in women. It is therefore important to understand t...

The purpose of this study is to evaluate whether glomerular C4d deposition can be a useful marker of disease activity in lupus nephritis. This is a 2 years study conducted from May 2010 to April 2012. Renal biopsies from 40 patients diagnosed as lupus nephritis are taken . Lupus nephritis incidence is more common in females (90%) and the mean patient age is 26±12.9 years. The most common clinic...

SUMMARY During the course of systemic lupus erythematosus in a 10 year-old girl, a go it er develo ped. Subc linical I ly pothyrnic.Jism was found, in addition rising titer of ant imicrosomal antibody and overt hypothyroidism after 6-week cessation of thyroxin tablet lead to the diagnosis of Hashimoto's thyroiditis. Antibodies directed to the thyroid may result in an autoimmune thyroiditis in...

Sheep injected every 2 weeks with heterologous GBM and Freund's adjuvant by any one or combination of the following routes: intramuscular, subcutaneous, or intradermal, develop uniformly a fulminating, extracapillary glomerulonephritis, invariably fatal within 27 to 90 days after the first injection. The chief histologic feature is marked fibroepithelial proliferation of Bowman's capsule with c...

BACKGROUND To perform a systematic review and network meta-analysis (NMA) to compare the risk of serious infections with immunosuppressive medications and glucocorticoids in lupus nephritis. METHODS A trained librarian performed two searches: (1) PubMed for all lupus nephritis trials from the end dates for the systematic review for the 2012 American College of Rheumatology (ACR) lupus nephrit...

Lupus nephritis always elicits immune inflammatory tissue damages in kidney. Pentraxin 3 (PTX3), mainly produced at inflammatory sites, is known to be involved in the regulation of the innate immunity system. The aim of this study was to investigate the serum and urine levels of PTX3, and the expression of PTX3 in renal tissues in lupus nephritis patients from a large Chinese cohort.The study u...

Systemic Lupus Erythematosus (SLE) frequently complicates into Nephritis (LN). At the time of diagnosis, a large proportion patients with SLE exhibit some form renal involvement. Even though African origin have higher incidence developing lupus nephritis as well presenting more severe underlying histopathology, there is limited data available on clinical characteristics and patterns in Tanzania.

BACKGROUNDS Patients with systemic lupus erythematosus (SLE) have an increased risk of acute myocardial infarction (AMI). We examined if nephritis or other clinical manifestations of SLE identified patients at increased risk. METHODS In this population-based case-control study, we identified patients with SLE hospitalized with an AMI in California in 1996-2000. We compared the frequency of si...