The highest incidence of seizures during lifetime is found in the neonatal period and neonatal seizures lead to a propensity for epilepsy and long-term cognitive deficits. Here, we identify potential mechanisms that elucidate a critical role for AMPA receptors (AMPARs) in epileptogenesis during this critical period in the developing brain. In a rodent model of neonatal seizures, we have shown p...

Commentary One of the most challenging questions in the neonatal intensive care unit (NICU) is how neonatal seizures should be treated. Currently used drugs work approximately half the time – good news for some patients but not for others (1). Medications designed for a physiologically older age group (i.e., non-neonates) may be less effective in neonates due to differences (compared with older...

OBJECTIVE To describe a novel neurophysiology based performance analysis of automated seizure detection algorithms for neonatal EEG to characterize features of detected and non-detected seizures and causes of false detections to identify areas for algorithmic improvement. METHODS EEGs of 20 term neonates were recorded (10 seizure, 10 non-seizure). Seizures were annotated by an expert and char...

Patricia A. Waltman is an associate professor in the school of nursing and a neonatal nurse practitioner at the University of Mississippi Medical Center in Jackson, Miss. She coordinates and teaches in the neonatal nurse practitioner track in the graduate nursing program. tion of antiepileptic drugs by the mother. Status epilepticus is an immediate threat to both mother and fetus and significan...