Hyperglycaemia is a common complication of prematurity and stress in neonatal intensive care units (NICUs). It has been linked to worsened outcomes and mortality. There is currently no universally accepted best practice glycaemic control method, with many protocols lacking patient specificity and relying heavily on clinical judgment. The result is persistent hypoglycaemia and poor control. This...

Hypoglycaemia is an important cause of cerebral damage in childhood. While much attention has recently been directed to its detection and treatment in the neonatal period, in later childhood the diagnosis is often delayed. There are many possible causes of hypoglycaemia in childhood, but in only a minority of cases is a precise diagnosis made, the majority being labelled 'idiopathic'. An insuli...

Carnitine-acylcarnitine translocase (CACT) deficiency is one of the fatty acid oxidation defects that presents early in the newborn period. It is known to be associated with a high mortality with a number of the earlier reported cases presenting as sudden infant death syndrome. Like most inborn errors of metabolism, presentation of CACT deficiency is rather non specific. Typical biochemical pro...

Context: Metformin therapy for treatment of GDM (Gestational Diabetes Mellitus) is not yet approved by FDA. Objectives: To assess the glycaemic control in women with GDM who received metformin therapy and to know the maternal side-effects and effects on the fetus-neonate. Material and Methods: A preliminary retrospective cohort analysis of 38 women with GDM who received metformin along with die...

INTRODUCTION Neonatal tetanus is a highly debilitating disease with high mortality. Global efforts at eliminating the disease in developing countries are yielding results but slower than expected. The high case fatality of neonatal tetanus remains a therapeutic challenge to physicians and requires continuous evaluation. This study aimed to determine the incidence and outcome of neonatal tetanus...

OBJECTIVE To investigate the association of neonatal hypoglycaemia and hyperglycaemia with outcomes in infants with hypoxic ischaemic encephalopathy (HIE). DESIGN Post hoc analysis of the CoolCap Study. SETTING 25 perinatal centres in the UK, the USA and New Zealand during 1999-2002. PATIENTS 234 infants at ≥36 weeks' gestation with moderate-to-severe HIE enrolled in the CoolCap Study. 21...