Background: The diagnosis of herpes simplex virus may requirevirological confirmation. Tzanck smear is an old, rapid, costeffective but nonspecific method that has been recently re-evaluatedas a method for the diagnosis of herpes virus infection. This studywas conducted to compare Tzanck smear and viral culture in thediagnosis of herpes simplex virus infection in patients clinicallysuspected to...

Neonatal Herpes simplex virus (HSV) infection is usually caused by type 2 virus following maternal peripartum genital HSV infection. Type 1 HSV usually affects infants after 3 months of age. Neonatal HSV infection present as skin, eye and mouth disease (SEM disease); affect the central nervous system (CNS disease) or involve multiple organs (Disseminated disease). Illustrative case: A full term...

Eight cases of disseminated herpes simplex infection unassociated with infantile eczema have been found at autopsy during the period September, 1957, to April, 1958. All but two of these were grossly malnourished. Herpetic stomatitis is very much more common than is generally appreciated. Routine studies carried out in our virus laboratory have revealed that many of the more severe and atypical...

Each year, about 1,600 infants in the United States are infected with neonatal herpes simplex virus. We conducted a cost-effectiveness analysis of antiviral drug therapy (acyclovir) for three forms of herpes simplex virus infection: skin, ear, and mouth (SEM), central nervous system (CNS), and disseminated multiorgan (DIS) disease. Five levels of patient outcomes were examined (normal, mild, mo...

Acyclovir resistance is not a recognized problem among neonates with perinatal herpes simplex virus (HSV) infection. A premature newborn with neurocutaneous HSV infection was treated for 21 days with acyclovir. Disseminated disease recurred 8 days later. A recurrent isolate was resistant to acyclovir and lacked thymidine kinase activity on the basis of a frameshift mutation in the thymidine kin...

Herpes Zoster is characterized with painful dermatomal blisters, which commonly seen in elderly or immuncompromised people. It caused by varicella zoster virüs (VZV). HIV infection known as a risk factor for herpes and developments of its complications. Cutaneous findings can be the presenting symptom infection. In presence infection, HZ prolong complicate evet recurrence rate increases. recurr...

BACKGROUND The development of suppressive therapy and type specific tests for herpes infections allow for screening to reduce the risk of neonatal herpes. OBJECTIVES To assess the potential effectiveness, cost effectiveness, and benefit of suppressive therapy among herpes simplex virus serodiscordant sex partners during pregnancy. METHODS Decision and economic analyses are used to compare t...

Background: Herpes simplex virus (HSV) encephalitis is the most common cause of sporadic encephalitis, with significant morbidity and mortality that are effectively reduced by antiviral treatment. Herpes simplex infection in pregnant women rarely results in encephalitis. The most common symptoms of a pregnant woman with herpes simplex infection are colds and skin vesicles. Herpetic encephalitis...