OBJECTIVES Efforts to improve the clinical outcome for patients with localized high-risk prostate cancer have led to the development of neoadjuvant systemic therapies. We review the different modalities of neoadjuvant therapies for localized prostate cancer and highlight emerging treatment approaches including immunotherapy and targeted therapy. METHODS We performed a PubMed search of clinica...

INTRODUCTION Treatment of cryptorchidism includes hormonal therapy and/or operative methods. To evaluate effectiveness of neoadjuvant hCG-therapy in cryptorchid boys regarding testicle position before and after treatment. MATERIAL AND METHODS 204 boys with 229 UDT, median age at presentation 6,6 years, SD ±3.4; 179 (87.7%) with unilateral and 25 (12.3%) with bilateral defect were treated betw...

•We present a case of cervical large cell neuroendocrine carcinoma (LCNEC) and neoadjuvant chemotherapy with irinotecan plus cisplatin that was extremely effective.•Cervical LCNEC is uncommon and highly aggressive, and optimal therapy has yet to be determined.•This case suggests that neoadjuvant chemotherapy followed by radical hysterectomy could be a useful treatment option for bulky cervical ...

HYPOTHESIS Patients receiving neoadjuvant chemoradiotherapy followed by surgery (CRS) undergo downstaging of their tumor and have improved survival when compared with patients undergoing surgery followed by adjuvant chemoradiotherapy (SCR). DESIGN Retrospective study. SETTING Tertiary-care university medical center. PATIENTS One hundred twenty-three patients with squamous cell carcinoma a...