Meningitis caused by gram-negative enteric bacteria usually is limited in children to the neonatal period. Among neonates, the disease is severe, with a mortality of up to 80%. The most common etiologic agent in this type of meningitis is Escherichia coli. Meningitis due to Citrobacter diversus has occurred in sporadic small outbreaks throughout the United States. This devastating disease frequ...

Cryptococcus neoformans (C. neoformans var. grubii and C. neoformans var. neoformans) and C. gattii are responsible for most cases of cryptococcal meningitis worldwide [1]. The disease of cryptococcal meningitis has been well documented in patients with acquired immune deficiency syndrome (AIDS) and it may also occur in human immunodeficiency virus (HIV)-negative patients even with apparently n...

background: acute bacterial meningitis is among serious infections of the central nervous system (cns). the early diagnosis and empiric antibiotic treatments have led to a reduction in morbidity and mortality rates. pcr and the enzymatic digestion of 16s rdna fragment following the pcr by universal primers led up fast and sensitive determination. the aims of the present study was to improve our...

A sandwich enzyme-linked immunosorbent assay was developed for its potential utility in the detection of antigen in the cerebrospinal fluid of patients with tuberculous meningitis. Cerebrospinal fluids examined included those from untreated (group Ia) and treated (group Ib) Mycobacterium tuberculosis meningitis, nonseptic central nervous conditions (group II) such as epilepsy, viral meningitis,...

AIM To compare presentation, progress, and outcome of acute bacterial meningitis in HIV seropositive and seronegative children. METHODS A double blind randomised placebo controlled study of the use of dexamethasone as adjuvant therapy in acute bacterial meningitis, in children aged 2 months to 13 years, was carried out from July 1997 to March 2001. A total of 598 children were enrolled, of wh...

Acute bacterial meningitis is an important cause of morbidity and mortality in children. To estimate the incidence of meningitis caused by all types of bacteria in Thai children under five years of age, data were collected using a rapid assessment tool (RAT) and analyzed. Clinical and laboratory data from suspected meningitis cases for a one-year period were retrospectively collected from 5 sel...

Appropriate, rapid and reliable laboratory tests are essential for the diagnosis and therapy of acute bacterial meningitis especially in children. The purpose of this study was to evaluate the diagnostic value of flowcytometric detection of CD64 surface marker on blood neutrophils in diagnosis of acute bacterial meningitis. Our work included 132 (74 males and 58 females) patients with suspected...

Tuberculous meningitis (TBM) and cryptococcal meningitis (CM) are two of the most common types of chronic meningitis. This study aimed to assess whether chronic neuro-psychological sequelae are associated with micro-structure white matter (WM) damage in HIV-negative chronic meningitis. Nineteen HIV-negative TBM patients, 13 HIV-negative CM patients, and 32 sex- and age-matched healthy volunteer...

background brain abscess is an infrequent complication of meningitis, including cases caused by gram-negative enteric bacteria and klebsiella in neonates. brain abscess in neonates associated with high morbidity and mortality.recently, incidence of the disease is increasing because of increased predisposing factors. patients and method three cases of brain abscess in neonates are reported, 2 of...

Meningitis remains a worldwide problem, and rapid diagnosis is essential to optimize survival. We evaluated the utility of a multiplex PCR test in differentiating possible etiologies of meningitis. Cerebrospinal fluid (CSF) from 69 HIV-infected Ugandan adults with meningitis was collected at diagnosis (n=51) and among persons with cryptococcal meningitis during therapeutic lumbar punctures (n=6...