Peanut and tree-nut allergies have increased dramatically in prevalence, especially children. Historically, children with food been treated through strict avoidance of the allergen. Recently, an oral preparation peanut allergen (Palforzia) was approved for immunotherapy (ie, desensitization) 4 to 17 years old. This article reviews its role allergies.

Abstract The immunomodulatory properties of probiotics are particularly important at the establishment Th 1-Th 2immune balance early in life. A skewing to response driven by dendritic cell regulation can lead airway alteration during respiratory allergy and virus infection. Previous work from our lab have determined that oral supplementation mice with Lactobacillus johnsonii (Lj) resulted be pr...

BACKGROUND Little information is available on the effect of allergen-specific immunotherapy on airway responsiveness and markers in exhaled air. The aims of this study were to assess the safety of immunotherapy with purified natural Alt a1 and its effect on airway responsiveness to direct and indirect bronchoconstrictor agents and markers in exhaled air. METHODS This was a randomized double-b...

Preparation of high quality allergen extracts is essential for the diagnosis and immunotherapy of allergic disorders. Standardization of allergen extracts concerns determination of the allergen unit, development of reference material and measurement of the overall IgE binding capacity of an allergen extract. Recently, quantification of individual allergens has been the main focus of allergen st...

Artemisia is the most important outdoor allergen throughout China. It can cause allergic rhinitis, asthma, or both of them. Since it was verified as an allergenic pollen in 1960, it was identified two times in the Chinese National Pollen Survey (1984, 2009). The first oral immunotherapy double-blinded trial for Artemisia pollen asthma research was conducted in China in 1989 and published in 199...

In the development of new antiallergic or antiasthmatic therapies, mouse models have helped to identify novel therapeutic agents. Before a medication is evaluated for potency in phase II and phase III studies in humans, different bronchial challenge models are used to test the efficacy and mode of action in small sample sizes. Most published trials follow a classical approach in which allergic ...

background: allergy to saffron (crocus sativus) pollen has been described in people involved in processing of saffron flower stamens. profilins have been identified as a pan-allergen in different plant pollens and foods. this molecule is an actin-binding pro-tein with a molecular weight of 12-16 kda found in eukaryotic species. objective: the aim of this study was to generate monoclonal antibod...

BACKGROUND Rat allergen has proved to be an important cause of IgE-mediated hypersensitivity in the occupational setting. The prevalence and significance of rat allergen in homes has not been studied. OBJECTIVE The purpose of this study was to determine the prevalence of rat allergen in the homes of inner-city children with asthma and to examine the relationship between rat allergen exposure,...

OBJECTIVE Allergic rhinitis (AR) is a disease with high and increasing prevalence. The management of AR includes allergen avoidance, anti-allergic drugs, and allergen specific immunotherapy (AIT), but only the latter works on the causes of allergy and, due to its mechanisms of action, modifies the natural history of the disease. Sublingual immunotherapy (SLIT) was proposed in the 1990s as an op...