The poor prognosis for patients with nasopharyngeal carcinoma is principally due to its advanced stage at the time of diagnosis. The symptoms and clinical findings at presentation of 56 patients with confirmed nasopharyngeal carcinoma is described and analysed. Recognising the common modes of presentation is essential to diagnose the disease at an early stage.

BACKGROUND AND OBJECTIVES Many studies have shown a negative association between the consumption of soy products and the risk of some cancers, but little is known about the effect of soy consumption on nasopharyngeal carcinoma. We assessed the association between the consumption of soy products on nasopharyngeal carcinoma risk in Chinese individuals. METHODS This case-control study included 6...

BACKGROUND Nasopharyngeal carcinoma (NPC) is a common malignancy in South-East Asia. NPC is characterized by distant metastasis and poor prognosis. The pathophysiological mechanism of nasopharyngeal carcinoma is unknown. This study aimed to identify the crucial miRNAs in nasopharyngeal carcinoma and their target genes, and to discover the potential mechanism of nasopharyngeal carcinoma developm...

BACKGROUND Nasopharyngeal carcinoma is a rare disease in most parts of the world with a multifactorial etiology involving an interaction of genetic, viral, environmental and dietary risk factors. This is the first epidemiologic study aimed to evaluate the risk factors of nasopharyngeal carcinoma in the Turkish population. METHODS We conducted a multicentric, retrospective, case-control study ...

Objectives: To establish the age-related distribution of clival marrow magnetic resonance imaging appearances in ethnic Chinese and to compare these findings with the clival marrow magnetic resonance imaging appearances seen in Chinese patients with nasopharyngeal carcinoma. Materials and Methods: T1-weighted sagittal cranial magnetic resonance images of 41 normal individuals and 40 patients ne...

OBJECTIVE Patients with nasopharyngeal carcinoma experience highly variable outcomes despite receiving similar therapeutic regimens. Identifying biomarkers that predict survival and guide individualized therapy is urgently needed. Cystatin C has been explored as a valuable prognostic marker in several malignancies. We retrospectively assessed the relationship between serum cystatin C levels and...

Nagaland has the highest AAR (age adjusted rates) of Nasopharyngeal carcinoma (NPC) in India. The frequent presentation metastatic neck nodes nasopharyngeal can lead to diagnostic errors if preliminary investigations are not done properly. We present two patients with NPC who were initially treated anti-tubercular therapy presumed have tuberculosis. Metastasis was confirmed fine needle aspirati...

BACKGROUND Treatment of nasopharyngeal carcinoma requires the application of high dosages of radiation, leading to severe long-term complications in the majority of patients. Sensitizing tumor cells to radiation could be a means to increase the therapeutic window of radiation. Nasopharyngeal carcinoma cells display alterations in autophagy and blockade of autophagy has been shown to sensitize t...

AIM To compare narrow-band images of nasopharyngeal carcinoma with those of normal adenoidal tissue. METHOD Patients with a nasopharyngeal mass were evaluated using both conventional white light and narrow-band light. Biopsies were performed and Epstein-Barr viral serology was tested for all patients. RESULTS Thirty consecutive patients were recruited. Twenty-one patients had normal adenoid...

AIMS AND BACKGROUND Thyroid metastasis from nasopharyngeal carcinoma is a rare occurrence. We report a case of thyroid metastases from nasopharyngeal carcinoma with a review of the literature. METHODS In April 2007 a 59-year-old man was diagnosed with nasopharyngeal carcinoma; in October 2009 he underwent a thyroid biopsy that revealed G2 infiltrating spinocellular carcinoma with lymph node i...