Numerous materials have been suggested for correction of nasal defects, especially for the saddle nose. We present here our experience with the autogenous cartilage transplant from the auricular concha in our collective of 32 patients. The concha cartilage is used for saddle nose corrections and reconstruction of the alar cartilages. Auricular concha cartilage is an almost ideal transplant mate...

Epiphyseal and growth plate cartilages from four cases of Kniest dysplasia have been studied. In each case collagen fibril organization appeared abnormal by electron microscopy compared with age-matched normal cartilages: fibrils were much thinner, of irregular shape and did not exhibit the characteristic banding pattern. This was associated with the absence (compared with normal cartilage) of ...

Skeletal tissues develop either by intramembranous ossification, where bone is formed within a soft connective tissue, or by endochondral ossification. The latter proceeds via cartilage anlagen, which through hypertrophy, mineralization, and partial resorption ultimately provides scaffolding for bone formation. Here, we describe a novel and essential mechanism governing remodeling of unminerali...

Cleft lip and palate (CLP) is the most common congenital deformity of the oral cavity. Recently, nasoalveolar moulding (NAM) has evolved as a presurgical technique which reduces the severity of the oronasal defect. NAM improves the facial appearance and function by moulding the nasal cartilages, premaxilla, and the alveolar ridges before the corrective surgical procedures. Utilization of the NA...

Relapsing polychondritis (RP) is a rare multisystemic disease characterized by recurrent inflammation of cartilaginous and noncartilaginous tissues. When laryngotracheal or bronchial cartilages are involved, the disease can be life-threatening and needs aggressive treatment. Upper airway complaints are rare as initial presentations of RP. Here, however, we present a case of RP, with initial man...

BACKGROUND Suspension sutures are commonly used in numerous cosmetic surgical procedures. Several authors have described the use of such sutures as a part of classical rhinoplasty. On the other hand, it is not uncommon to see patients seeking nasal surgery for only a minimal hump deformity combined with an underrotated, underprojecting tip, which does not necessarily require all components of r...

BACKGROUND Relapsing polychondritis (RP) is a rare autoimmune disease of unknown etiology that may affect multiple cartilage throughout the body. CASE REPORT We report on a middle-aged man presented with cough, chest tightness, and fever of unknown origin, 18F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) was performed. And the imaging shows multiple incre...

Using both mutant analyses with zebrafish mutants deficient in genes encoding members of this signaling pathway, as well as pharmacological treatment with cyclopamine, which inhibits Hh signaling, we have gained a better understanding of the role of this signaling pathway on branchial arch outgrowth. We conclude that while Hh is involved in cell proliferation within all pharyngeal cartilages, i...