Background: Narcotic abuse by people accounts for major problems for developing countries such as Iran. Acute narcotic poisoning is one of the major mortality causes in these patients. The present study was designed to assess the clinical signs and symptoms of patients with narcotic poisoning at hospitals of Yazd. Methods: In this study, 500 patients with narcotic poisoning were assessed fro...

We have previously reported that the administration of cyclo(Leu-Gly) to mice prior to morphinization blocked the development of tolerance to the analgesic effects of morphine as well as the development of some signs of physical dependence. In the present series of experiments, the effect of the same peptide treatment on changes in dopamine receptor sensitivity induced by chronic morphine treat...