Silver nanoparticles (AgNPs) are important and widely used as antimicrobials nanodrug carriers. The increased use of AgNPs in consumer products has raised concerns about nanosafety; for instance, may be inhaled translocated to the brain via olfactory neural stem cells/progenitors. While biological effects nanoparticle size have been investigated, there little data on particle shape cellular phe...

Abstract Arsenic trioxide (ATO) is a promising chemotherapeutic agent, but its clinical application limited due to poor pharmacokinetics and dose-limited toxicity. Moreover, the combination of ATO sec-o-glucosylhamaudol (SOG) can improve therapeutic effect hepatoma. In this study, PEGylated magnetic nanographene oxide (PEG@MGO) was used as carriers enhance targeting ability drug delivery system...

Hepatocellular carcinoma or hepatoma is a primary malignant neoplasm that responsible for 75–90% of all liver cancer in humans. Nanotechnology introduced the dual drug nanodelivery method as one initiatives nanomedicine therapy. Graphene oxide (GO) loaded with protocatechuic acid (PCA) and chlorogenic (CA) have shown some anticancer activities both passive active targeting. The physicochemical ...

A nanodrug delivery system of paclitaxel-mesoporous silica nanoparticles with a core-shell structure (PAC-csMSN) was used to increase the dissolution of paclitaxel (PAC) and improve its treatment of lung cancer. PAC was loaded into the core-shell mesoporous silica nanoparticles (csMSN) by the adsorption equilibrium method and was in an amorphous state in terms of its mesoporous structure. In vi...

The 2D monolayer cell culture model is often the first step in the prediction of the success or failure of a nanoparticle-based drug delivery system. However, there is often poor translation between the 2D monolayer in vitro results and the nanoparticle-drug performance in vivo. One possible way of bridging this gap is the use of multicellular tumor spheroids (MCTSs) as an intermediate in vitro...

Physicochemical properties, including particle size, zeta potential, and drug release behavior, affect targeting efficiency, cellular uptake, and antitumor effect of nanocarriers in a formulated drug-delivery system. In this study, a novel stepwise pH-responsive nanodrug delivery system was developed to efficiently deliver and significantly promote the therapeutic effect of doxorubicin (DOX). T...

The aim of the present study was to investigate the antitumor effects and possible mechanism of (-)-gossypol nanoparticles, loaded with vv polyethylene glycol-maleimide (mPEG-Mal), in vitro. Emulsification-volatilization was used to prepare the loaded (-)-gossypol nanoparticles. The toxicity of blank nanoparticles on human prostate cancer PC-3 cells and human prostate RWPE-1 cells was measured....

Biomaterials play a pivotal role in regenerative medicine, which aims to regenerate and replace lost/degenerated tissues or organs. Natural bone is a hierarchical structure, comprised of various cells having specific functions that are regulated by sophisticated mechanisms. However, the regulation of the normal functions in damaged or injured cells is disrupted. In order to address this problem...