We measure the thermal fluctuation of the internal segments of a piece of DNA confined in a nanochannel about 50-100 nm wide. This local thermodynamic property is key to accurate measurement of distances in genomic analysis. For DNA in ~100 nm channels, we observe a critical length scale ~10 m for the mean extension of internal segments, below which the de Gennes' theory describes the fluctuati...

A radically novel approach towards isotachophoresis is presented in which a nanochannel-induced ionic depletion zone replaces a trailing electrolyte. This makes depletion zone isotachophoresis (dzITP) a single-electrolyte focusing and separation technique. Moreover, focusing strength and positions of analyte zones can be precisely controlled by a three-point voltage actuation scheme. Thus, dzIT...

Polyelectrolyte (PE) grafting on the solid-liquid interface of a nano-channel renders tremendous functionalities to the nano-channel. These grafted PE molecules attain "brush"-like configuration for large grafting density (σ), which makes the nano-channel (often denoted as soft nanochannel) capable of applications such as ion manipulation, ion sensing, current rectification, nano-fluidic diode ...

The development of pH gated glucose (Glu) biosensor is of great significance to human health. Herein, we have designed a pH gated Glu responsive biomimetic nanochannel, modified with 3-aminobenzeneboronic acid. The Glu responsive property can be regulated by pH which can switch nanochannels from the "on" to "off" state.

A living cell interrogation platform based on nanochannel electroporation is demonstrated with analysis of RNAs in single cells. This minimally invasive process is based on individual cells and allows both multi-target analysis and stimulus-response analysis by sequential deliveries. The unique platform possesses a great potential to the comprehensive and lysis-free nucleic acid analysis on rar...

A colloidal damper (CD) can dissipate a significant amount of vibrations and impact energy owing to the interface power that is generated when it used. It great practical significance study influence nanochannel structure hydrophobic silica gel in CD damping medium on running speed CD. The fractal theory was applied observe characteristics micropore by scanning electron microscopy (SEM), primar...