Various ratios PEOz-PDLLA diblock copolymers were synthesized through ring-opening polymerization of DL-lactide initiated by monohydroxyl terminated poly(2-ethyl-2-oxazoline) (PEOz-OH). The chemical composition and molar mass the resulting determined using NMR GPC. Spherical micelles with a diameter from 104 to 136 nm obtained via self-assembly in water, as evidenced TEM DLS. CMC was well below...

Micelles from self-assembled amphiphilic copolymers are highly attractive in drug delivery, due to their small size and hydrophilic stealth corona allowing prolonged lifetimes the bloodstream thus improved bioavailability. Polylactide (PLA)-based copolymer micelles key candidates this field, owing well-established biodegradability biocompatibility of PLA. While PLA-b-poly(ethylene glycol) (PEG)...

Pyrrole-functionalized imidazolium surfactants PyCnMImBr with different alkyl chain lengths (n = 8, 10, 12) were synthesized and their aggregation properties in water investigated by tensiometry conductimetry. These studies show that present lower critical micellar concentration than non-functionalized analogues due to (i) an increased hydrophobicity resulting from the extension of length upon ...

The concept of utilizing polymers in drug delivery has been extensively explored for improving the therapeutic index of small molecule drugs. In general, polymers can be used as polymer-drug conjugates or polymeric micelles. Each unique application mandates its own chemistry and controlled release of active drugs. Each polymer exhibits its own intrinsic issues providing the advantage of flexibi...

The dynamical properties of nanogels of xanthan gum (XG) with hydrodynamic radius controlled in a size range from 5 nm to 35 nm, were studied at the different XG concentrations in water/sodium bis-2-ethylhexyl-sulfosuccinate (AOT)/decane reverse micelles (RMs) vs. mass fraction of nano-droplet (MFD) at W = 40, using dynamic light scattering (DLS). The diffusion study of nanometer-sized droplets...

With the advent of multifunctional nano delivery systems, simultaneous imaging and therapy aspires to detect and treat tumors at a very early stage with promising out‐ comes. In this context, numerous anti-cancer drug/gene delivery systems have been ex‐ plored with the primary aim to increase the treatment efficacy without compromising safety. Secondary goals include enhancing bioavailability, ...

In the present research, the D-(+)-Glucose–confined water nanodroplets with mean size in the range of 6-11 nm were synthesized at D-(+)-Glucose different concentrations by AOT reverse micelles (RMs) method as a function of mass fraction of droplet (MFD) at the constant water-to-surfactant molar ratio ( W=40). The dynamic light scattering of the nano-sized water droplets containing the D-(+)-Glu...

One of the key challenges in the development of nano carriers for drug delivery and imaging is the design of a system that selectively binds to target cells. A common strategy is to coat the delivery device with specific ligands that bind strongly to overexpressed receptors. However such devices are usually unable to discriminate between receptors found on benign and malignant cells. We demonst...

Nano-oncology is a branch of biomedical research and engineering that focuses on using nanotechnology in cancer diagnosis treatment. Nanomaterials are extensively employed the field oncology because their minute size ultra-specificity. A wide range nanocarriers, such as dendrimers, micelles, PEGylated liposomes, polymeric nanoparticles used to facilitate efficient transport anti-cancer drugs at...