Spatial computing, as implemented on reconfigurable platforms, such as FPGAs, presents an effective solution to high performance computing applications where computations are applied repeatedly to streams of data. Bridging the gap between program descriptions and hardware system implementations, however, is a challenging problem. ROCCC is a C/C++ to VHDL compiler that focuses on extensive loop,...

Gaussian accelerated molecular dynamics (GaMD) is a recently developed enhanced sampling technique that provides efficient free energy calculations of biomolecules. Like the previous accelerated molecular dynamics (aMD), GaMD allows for "unconstrained" enhanced sampling without the need to set predefined collective variables and so is useful for studying complex biomolecular conformational chan...

These recommendations, produced by a group of Canadian retina experts, have been developed to assist both specialists and general ophthalmologists in the management vision-threatening neovascular age-related macular degeneration (nAMD). The recommendations are based on published evidence as well collective experience expertise routine clinical practice. We provide an update practice principles ...

Abstract Optical coherence tomography angiography (OCTA) has been a frequently used diagnostic method in neovascular age-related macular degeneration (nAMD) because it is non-invasive and provides comprehensive view of the characteristic lesion, choroidal neovascularization (CNV). In order to study its characteristics, an automated needed identify quantify CNV. Here, we have developed deep lear...

: This narrative review highlights routes of ocular drug delivery for age-related macular degeneration (AMD). AMD is the leading cause irreversible blindness in industrialized countries and accounts 8.7% worldwide. Advanced can be classified into two subtypes: late-stage dry [known as geographic atrophy (GA)] neovascular (nAMD). GA often bilateral results from progressive loss photoreceptors ar...

Objective: To evaluate vision-related quality of life (QoL) using National Eye Institute Visual Function Questionnaire-25 (NEI-VFQ-25) in neovascular age-related macular degeneration (nAMD) patients during coronavirus disease-2019 (COVID-19) pandemic. Material and Methods: nAMD whose intravitreal injection had to be postponed due restrictions COVID-19 lockdown between April June 2020, NEI-VFQ-2...

PURPOSE Age-related macular degeneration (AMD) is thought to be a polygenetic disease. It is divided into three subtypes; neovascular AMD (nAMD), polypoidal choroidal vasculopathy, and retinal angiomatous proliferation (RAP). These subtypes are thought to have different pathophysiological and genetic backgrounds. We aimed to investigate the relationships between single nucleotide polymorphisms ...