The present experiment evaluated whether prior treatment with naloxone could block the sensitization to opiate antagonist induced by single dose administration of pure agonist (morphine) or mixed agonist (buprenorphine). Food deprived male Wistar rats were trained to respond for food on a multiple-trial, fixed-interval 3 min schedule. Reinforcement was contingent upon a response within a 10-s l...

Object exploration was examined in naloxone injected (1 mg/kg or 4 mg/kg) and saline control rats. Naloxone rats explored an object for a shorter time than did controls, thus indicating a lower investigatory motivation. This effect was dose dependent. Higher drug dose (4 mg/kg) decreased the number of contacts with an object. Both doses increased the mean duration of contacts with an object. Th...

BACKGROUND AND PURPOSE In a previous study, we occasionally found that the rat given naloxone in the preoptic region develops behavioral seizures. In view of knowledge that the forebrain including the medial septal nucleus provides cholinergic projections to the hippocampal formation, the present study examined the effects of naloxone injected into the medial septal nucleus on the local blood f...

if lives were saved on only 10% of these occasions, then each would have been saved at a drug cost of £330-670. The range of doses given raises the possibility that naloxone was being titrated to effect resuscitation without provoking withdrawal. If so, recovery needs monitoring to avoid subsequent relapse into overdose. Some casualty departments and ambulance services now recommend giving nalo...

Opioid treatment of pain is generally safe with 0.5% or less events from respiratory depression. However, fatalities are regularly reported. The only treatment currently available to reverse opioid respiratory depression is by naloxone infusion. The efficacy of naloxone depends on its own pharmacological characteristics and on those (including receptor kinetics) of the opioid that needs reversa...

The effect of naloxone on GnRH-induced LH and FSH release was measured in buffaloes in luteal phase of estrous cycle. Animals were administered intravenously, naloxone/saline (50 mg/injection) every 15 min for 3 hr followed by GnRH (100 micrograms). Peripheral plasma LH and FSH concentrations were measured in blood samples collected at 15 min intervals from 1 hr prior to beginning of naloxone/s...

Michael A. Yokell, ScB, Traci C. Green, MSc, PhD, Sarah Bowman, MPH, Michelle McKenzie, MPH, and Josiah D. Rich, MD, MPH  introduCtion Opioid overdose is a major public health concern that affects a diverse group of individuals across all categories of race, class, and geography. Overdose is the leading cause of adult accidental death in Rhode Island, making our state one of only 16 where over...

BACKGROUND Several diseases affect bone healing and physiology. Many drugs that are commonly used in orthopaedics as "analgesics" or anti-inflammatory agents impair bone healing. Stressful conditions are associated with decreased serum osteocalcin concentration. High endorphin levels alter calcium metabolism, blocking the membrane channels by which calcium normally enters cells. The consequent ...

We determined the effect of the opiate receptor antagonist naloxone on aggression, emotion, feeder control, and eating behavior in high and low aggression female pigeons maintained at 80% of their normal weight and exposed to food competition interactions. Pigeons were divided into pairs by previously ranked high aggression (total time spent in offensive aggression exceeding 60 s/5 min; N=6 pai...

BACKGROUND AND OBJECTIVES Opioid users in treatment are at high risk of relapse and overdose, making them an important target for efforts to reduce opioid overdose mortality. Overdose Education (OE) is one such intervention, and this study tests the effectiveness of OE in a community substance use disorder treatment program. METHODS Opioid users were recruited from a community treatment cente...