نتایج جستجو برای: nadph

تعداد نتایج: 21368  

Journal: :Molecules 2012
Hongmei Chen Bo Zhang Ying Yao Na Chen Xiaoyu Chen Hui Tian Zhenhua Wang Qiusheng Zheng

The present study was undertaken to test the hypothesis that NADPH oxidase-derived reactive oxygen species (ROS) are involved in isoliquiritigenin (ISL)-induced monocytic differentiation in human acute promyelocytic leukemia HL-60 cells. Morphological changes, cell surface markers CD11b/CD14 and NBT-reducing ability were used to determine the differentiation of HL-60 cells, and 2,7-dichlorofl...

2004
M. E. BICKFORD

We investigated the source of axons and terminals in the cat's lateral geniculate nucleus that stain positively for NADPH-diaphorase. The functional significance of such staining is that NADPH-diaphorase is identical to the enzyme nitric oxide synthetase, and thus it is thought to reveal cells and axons that use nitric oxide as a neuromodulator. Within the lateral geniculate and adjacent perige...

Journal: :American journal of respiratory and critical care medicine 2005
Guanxia Zhan Faridis Serrano Polina Fenik Ray Hsu Linghao Kong Domenico Pratico Eric Klann Sigrid C Veasey

RATIONALE Persons with obstructive sleep apnea may have significant residual hypersomnolence, despite therapy. Long-term hypoxia/reoxygenation events in adult mice, simulating oxygenation patterns of moderate-severe sleep apnea, result in lasting hypersomnolence, oxidative injury, and proinflammatory responses in wake-active brain regions. We hypothesized that long-term intermittent hypoxia act...

Journal: :The Journal of biological chemistry 1977
L N Csonka D G Fraenkel

NADPH formation during growth on glucose was studied in wild type Escherichia coli and in mutants affected, directly or indirectly, in the NADPH-forming reactions glucose-6-phosphate dehydrogenase, isocitrate dehydrogenase, malate dehydrogenase, and energy-linked transhydrogenase. The main technique was to grow cells in media containing glucose labeled uniformly with ‘“C and also containing glu...

Journal: :Stroke 2007
Alyson A Miller Grant R Drummond Anja E Mast Harald H H W Schmidt Christopher G Sobey

BACKGROUND AND PURPOSE This study tested whether NADPH-oxidase activity, expression, and functional effects on vascular tone are influenced by gender in the rat cerebral circulation and whether such differences are estrogen-dependent. METHODS NADPH-stimulated superoxide production by cerebral (basilar [BA]; middle cerebral) arteries from male and female Sprague-Dawley rats was measured using ...

2016
Ewa Kilanczyk Sujata Saraswat Ohri Scott R. Whittemore Michal Hetman

The pentose phosphate pathway is the main source of NADPH, which by reducing oxidized glutathione, contributes to antioxidant defenses. Although oxidative stress plays a major role in white matter injury, significance of NADPH for oligodendrocyte survival has not been yet investigated. It is reported here that the NADPH antimetabolite 6-amino-NADP (6AN) was cytotoxic to cultured adult rat spina...

Journal: :The Biochemical journal 2005
Gábor L Petheo Nicolas Demaurex

The phagocytic NADPH oxidase generates superoxide by transferring electrons from cytosolic NADPH to extracellular O2. The activity of the oxidase at the plasma membrane can be measured as electron current (I(e)), and the voltage dependence of I(e) was recently reported to exhibit a strong rectification in human eosinophils, with the currents being nearly voltage independent at negative potentia...

Journal: :American journal of physiology. Heart and circulatory physiology 2010
Nageswara R Madamanchi Marschall S Runge

NADPH OXIDASE (NOX)-mediated generation of reactive oxygen species (ROS) was first described in phagocytic cells, and for many years it was assumed that the primary role of NADPH oxidase activation was bacteriocidal; phagocytes generated a burst of ROS following activation. More recently, it has become clear that not only do multiple homologous NADPH oxidase subunits exist but that the expressi...

2010
Brahm H. Segal Wei Han Jennifer J. Bushey Myungsoo Joo Zahida Bhatti Joy Feminella Carly G. Dennis R. Robert Vethanayagam Fiona E. Yull Maegan Capitano Paul K. Wallace Hans Minderman John W. Christman Michael B. Sporn Jefferson Chan Donald C. Vinh Steven M. Holland Luigina R. Romani Sarah L. Gaffen Michael L. Freeman Timothy S. Blackwell

BACKGROUND Chronic granulomatous disease (CGD), an inherited disorder of the NADPH oxidase in which phagocytes are defective in generating superoxide anion and downstream reactive oxidant intermediates (ROIs), is characterized by recurrent bacterial and fungal infections and by excessive inflammation (e.g., inflammatory bowel disease). The mechanisms by which NADPH oxidase regulates inflammatio...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید