The efflux of Mg++ from squid axons subject to internal solute control by dialysis is a function of ionized [Mg], [Na], [ATP], and [Na]o. The efflux of Mg++ from an axon with physiological concentrations of ATP, Na, and Mg inside into seawater is of the order of 2-4 pmol/cm2s but this efflux is strongly inhibited by increases in [Na]i, by decreases in [ATP]i, or by decreases in [Na]o. The efflu...

Mg-extrusion from Mg-loaded neurons of the leech, Hirudo medicinalis, is mediated mainly by Na/Mg antiport. However, in a number of leech neurons Mg is extruded in the nominal absence of extracellular Na, indicating the existence of an additional, Na-independent Mg transport mechanism. This mechanism was investigated using electrophysiological and microfluorimetrical techniques The rate of Na-i...

Thermosensitive injectable hydrogels based on chitosan neutralized with sodium beta-glycerophosphate (Na-β-GP) have been studied as biomaterials for drug delivery and tissue regeneration. Magnesium (Mg) has been reported to stimulate adhesion and proliferation of bone forming cells. With the aim of improving the suitability of the aforementioned chitosan hydrogels as materials for bone regenera...

The marine alga Valonia macrophysa contains in its cell sap K and Na in the proportion of 5.72 to 1. In a form regarded as closely related, Valonia ventricosa, growing in similar environment, the ratio of K to Na is as 0.0278 to 1. The former contains no Mg but in the latter it is present. There are other differences in the composition of the sap. These differences bring about a remarkable cont...

We measured renal functions and hormones associated with fluid regulation after a bolus injection of aldosterone (Ald) during head-down tilt (HDT) bed rest to test the hypothesis that exposure to simulated microgravity altered renal responsiveness to Ald. Six male rhesus monkeys underwent two experimental conditions (HDT and control, 72 h each) with each condition separated by 9 days of ambulat...

Background: The effects of aqueous extract of Fadogia agrestis stem at the doses of 18, 36, and 72 mg/kg body weight on alloxan-induced toxicity was investigated in Wistar rats. Methods: In total, 35 rats of both sexes (132.80±7.22g) were randomized into five groups (A-E): animals in group A received 0.5 ml of distilled water orally on daily basis for 15 days while the alloxanized rats in gr...

In non Mg-loaded and non malaria-infected rat erythrocytes, mefloquine (100 lmol·l) stimulated choline/Mg antiport without affecting the Na/Mg antiport. The stimulation of the choline/Mg antiport by mefloquine, found in this study, and by trifluoperazine and fluvoxamine, reported previously [Ebel et al. Biochim Biophys Acta 2004; 1167: 132-40], was associated with CF3 groups attached to the qui...