Gastrointestinal disturbances, such as nausea and vomiting, are considered amongst the main adverse effects associated with oral anticancer drugs due to their fast release in the gastrointestinal tract (GIT). Sustained release formulations with proper release profiles can overcome some side effects of conventional formulations. The current study was designed to prepare sustained release tablets...

The aim of the present study was to formulate and investigate the calcium alginate- (CA-) Neusilin US2 nanocomposite microbeads containing preconcentrate of aceclofenac sodium (ACF-Na) liquid microemulsion (L-ME) for enhancement of oral bioavailability. The preconcentrate L-ME is prepared by using Labrafac PG, Labrasol, and Span 80 as oil, surfactant, and cosurfactant, respectively. The solid C...

New catalytic materials, based on palladium immobilized in ionic liquid supported on alginate, were elaborated. Alginate was associated with gelatin for the immobilization of ionic liquids (ILs) and the binding of palladium. These catalytic materials were designed in the form of highly porous monoliths (HPMs), in order to be used in a column reactor. The catalytic materials were tested for the ...

The aim of this study was to evaluate the effects of alginate entrapment on fermentation metabolites of Kluyveromyces marxianus grown in agrowastes that served as the liquid culture media. K. marxianus cells entrapped in Na-alginate were prepared using the traditional liquid-droplet-forming method. Whey and pomaces from processed tomatoes, peppers, and grapes were used as the culture media. The...

Abbreviations: T1D: Type 1 Diabetes; PCO: Pericapsular Overgrowth; OCR: Oxygen Consumption Rate; HBO: Hyperbaric Oxygen Therapy; EX-4: Exendin-4; FGF-1: Fibroblast Growth Factor – 1; aFGF: acidic Fibroblast Growth Factor; VEGF: Vascular Endothelial Growth Factor;VEGFR2: Vascular Endothelial Growth Factor Receptor 2; AMPK: Adenosine Monophosphate Activated Protein Kinase ; NFκB: Nuclear Factor κ...

The opportunistic pathogen Pseudomonas aeruginosa secretes a capsule-like polysaccharide called alginate that is important for evasion of host defenses, especially during chronic pulmonary disease of patients with cystic fibrosis (CF). Most proteins for alginate biosynthesis are encoded by the 12-gene algD operon. Interestingly, this operon also encodes AlgL, a lyase that degrades alginate. Mut...

The exopolysaccharide alginate of Pseudomonas aeruginosa was shown to be important in determining the degree of cell detachment from an agar surface. Nonmucoid strain 8822 gave rise to 50-fold more sloughed cells than mucoid strains 8821 and 8830. Alginate anchors the bacteria to the agar surface, thereby influencing the extent of detachment. The role of the P. aeruginosa alginate lyase in the ...

The purpose of this study was to synthesize biomaterials from daily dental waste. Since alginate impression material contains silica and calcium salts, we aimed to synthesize calcium silicate cement from alginate impression material. Gypsum-based investment material was also investigated as control. X-ray diffraction analyses revealed that although firing the set gypsum-based and modified inves...

Two fully human mAbs specific for epitopes dependent on intact carboxylate groups on the C6 carbon of the mannuronic acid components of Pseudomonas aeruginosa alginate were found to promote phagocytic killing of both mucoid and nonmucoid strains as well as protection against both types of strains in a mouse model of acute pneumonia. The specificity of the mAbs for alginate was determined by ELI...

Due to the relatively poor cell-material interaction of alginate hydrogel, alginate-gelatin crosslinked (ADA-GEL) hydrogel was synthesized through covalent crosslinking of alginate di-aldehyde (ADA) with gelatin that supported cell attachment, spreading and proliferation. This study highlights the evaluation of the physico-chemical properties of synthesized ADA-GEL hydrogels of different compos...