The third-generation, irreversible tyrosine kinase inhibitor osimertinib is first-line treatment for advanced non-small cell lung cancer (NSCLC) with mutated epidermal growth factor receptor (EGFR). Pre-clinical studies have shown synergistic anti-tumor activity of osmertinib and radiotherapy. However, the safety radiotherapy concurrent has not been reported. Medical records all patients EGFR-m...

The k·p theory allows to describe the band structure analytically. After the pioneering work by Luttinger and Kohn [1] the six-band k·p method has become widely used to model the valence band in silicon. The conduction band in silicon is usually approximated by three pairs of equivalent minima located near the Xpoints of the Brillouin zone. It is commonly assumed that close to the minima the el...

In this document we describe the scheme used for labelling the open-source Ukwabelana Zulu corpus as well as the rules employed for the Part-of-speech (POS) tagger used to assign POS to morphologically analysed words. A detailed description of the Zulu morphology, the corpus itself and its generation is given in [2]. All resources can be downloaded from http://www.cs.bris.ac.uk/Research/Machine...

Genetic Algorithm Combining Operation Tree (GAOT) was constructed to estimate the slump flow of high-performance concrete (HPC) by using seven concrete ingredients. HPC is a highly complex material; because modeling its behavior is extremely difficult, robust optimization techniques are required. GAOT is a type of evolutionary algorithm that simultaneously optimizes functions and their associat...

Background: Relatively little is known about the genetic basis for the unique physiology of metalreducing genera in the delta subgroup of the proteobacteria. The recent availability of complete finished or draft-quality genome sequences for seven representatives allowed us to investigate the genetic and regulatory factors in a number of key pathways involved in the biosynthesis of building bloc...

Lung cancer screening with a low radiation dose chest CT scan is the standard of care for screening-eligible individuals. The net benefit may be optimized by delivering high-quality care, capable maximizing and minimizing harms screening. Valid, feasible, relevant indicators quality lung help programs to evaluate their current practice develop improvement plans. purpose this project was related...

Background: We consider the problem of identifying the dynamic interactions in biochemical networks from noisy experimental data. Typically, approaches for solving this problem make use of an estimation algorithm such as the well-known linear Least-Squares (LS) estimation technique. We demonstrate that when time-series measurements are corrupted by white noise and/or drift noise, more accurate ...

The United States Air Force Weather operates globally to collect observations of atmospheric conditions. Instruments include human observers, weather satellites, and weather radars. A new era is forthcoming in the domain of weather satellites, as satellite sensors are improved and additional weather satellites are launched by China, Japan, and others. The United States is integrating its civili...

2014 We describe the defect structure of a tetrahedral close packed model. Defects appear as a hierarchy of interlaced disclination networks which form the locus of sites where the local order deviates from a perfect icosahedral environment. This defect structure is generated by an iterative process which gradually decreases the curvature of an ideal polytope model. Tome 45 No 17 ler SEPTEMBRE ...