SUMMARY The macromolecular binding of radioactivity from 1-(2-chiorethyl)-3-cyclohexyl-1-nitrosourea, labeled with ‘@ C in either the cyclohexyl moiety or the ethylene residue, was studied in the L1210 leukemia-bearing mice, in a suspension of Ll2lO leukemia cells, and during in vitro incubation with isolated nucleic acids and proteins. In all three systems, radioactivity from @ C-labeled 1-(...

The physiological disposition of l-(2-chloroethyl)-3cyclohexyl-1-nitrosourea, a highly active agent against intraperitoneal and intracranial mouse leukemia L1210, was studied in mice, rats, dogs, and monkeys with the 14C label in each of 3 positions of the molecule, the ethylene, carbonyl, and cyclohexyl moieties. l-(2-Chloroethyl)-3-cyclohexyl-l-nitrosourea is lipid soluble and, after parenter...

The toxic effects of the combinations of amphotericin B (AmB) and actinomycin D or AmB and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea were measured against the human promyelocytic leukemia cells HL-60. The toxicities of both drug combinations were greater than the additive toxicity of each of the drugs used singly, but the exact conditions under which synergism was achieved differed for each ...

Thirty-six patients with advanced gastrointestinal carcinoma were treated sequentially with full therapeutic doses of l-(2-chloroethyl)-3-cyclohexyl-l-nitrosourea followed by 5-fluorouracil. 5-Fluorouracil could be safely administered at 6 weeks although patients still demonstrated peripheral hematological depression secondary to the earlier l-(2-chloroethyl)-3-cyclohexyl-l-nitrosourea therapy....

The aim of this study was to clarify the mechanism of the potentiation by amphotericin B (AMB) of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) antineoplastic effects on s.c. murine ependymoblastoma. The effect of AMB on tumor cell permeability to CCNU labeled on the cyclohexyl moiety was studied. The radioactivity measured in ependymoblastoma 1, 6, 14, and 25 hr after i.m. injection of 1...