BackgroundAgeing is associated with an impaired immune response and shares many physiological alterations observed in HIV chronic infection; therefore, we hypothesised that people living exhibit a premature ageing phenotype, reflected by age-related changes the plasma proteome.MethodsWe profiled proteome two cohorts of virally suppressed HIV, 2000HIV cohort (n=65; median age 53 years [IQR 45–60...

Square-wave cathodic adsorptive stripping voltammetry based on adsorptive accumulation is a very sensitive technique for the trace determination of xanthosine 50-monophosphate (50-XMP) and xanthosine 50-diphosphate (50-XDP). The determination is based on the strong interaction of the adsorption of xanthosine phosphate compounds on a mercury electrode surface, forming Hg(II)-xanthate. The cathod...

Background: The COVID-19 pandemic is expected to have impacted patient management on a global level. However, the degree of impact and prescribing strategy in fields rheumatology, dermatology gastroenterology unclear. Objectives: Assess across EU US, as described by rheumatologists, dermatologists, gastroenterologists. Methods: Data were drawn from physician surveys France, Germany, Italy, Spai...

All-AlGaN based high electron mobility transistors (HEMTs) are promising for increasing the power density in both RF and devices, improving overall efficiency. Nitrogen (N) polar GaN/AlGaN HEMTs offer lower contact resistance compared to its metal-polar counterpart. In this work, we report metal organic chemical vapor deposition (MOCVD)-based growth of N-polar AlGaN channel HEMT structures with...

We aimed to evaluate whether the use of a speculum blade modifies the evaluation of pelvic organ prolapse (POP) as assessed by dynamic magnetic resonance imaging (MRI). Twenty-seven women with POP Quantification (POPQ) stage II or greater, scheduled for POP surgery, were evaluated using MRI. The procedure was repeated using the posterior blade of a standard plastic Grave's speculum to successiv...

Background Patients with psoriatic disease(PsD) [psoriasis(PsO) and arthritis(PsA)] are at greater risk of non-alcoholic fatty liver disease(NAFLD) NAFLD-associated fibrosis/cirrhosis compared the general population other inflammatory arthritis(1) independent disease-modifying medications [biological(b)DMARDs or methotrexate(MTX)][2]. Conversely, using these in patients significant NAFLD might ...

Immunity against Theileria parva is associated with CD8 T-cell responses that exhibit immunodominance, focusing the response against limited numbers of epitopes. As candidates for inclusion in vaccines, characterization of responses against immunodominant epitopes is a key component in novel vaccine development. We have previously demonstrated that the Tp249-59 and Tp1214-224 epitopes dominate ...