There is a robust polyatomic chemistry in diffuse, partially-molecular interstellar gas that readily accessible absorption at radio/mm/sub-mm wavelengths. Accurate column densities are derived owing to the weak internal excitation, so relative molecular abundances well known with respect each other but not H2. Here we consider use of proxies for hydrogen N(H2) and N(H) = N(HI)+2N(H2) based on m...

Aim - an analysis of levels steroid hormones in heart cell mitochondria at the stages B16/F10 melanoma development combination with chronic neurogenic pain male and female C57BL/6 mice. The study included mice (n=336). Experimental groups were: intact animals (♂ n=21; ♀ n=21); controls n=21) a model (CNP); comparison group n=63; n=63) melanomas (B16/ F10); main (CNP+B16/F10) transplanted 3 week...

OBJECTIVE To study the interaction between human steroid 21-hydroxylase (21-OH) and monoclonal antibodies (MAbs) to 21-OH directed to 3 different epitopes recognised by 21-OH autoantibodies characteristic of autoimmune Addison's disease. DESIGN Build comparative structural models of 21-OH, 21-OH MAbs and complexes of 21-OH-21-OH MAbs and study the effects of 21-OH MAbs on 21-OH enzyme activit...

The IL21R gene is comprised of 9 exons (+2 alternative first exons), spanning 48.4kb on chromosome 16p11 (Parrish-Novak, 2000). The human IL21R promoter region, contained within nucleotides -789 to +195 (relative to the start of exon 1a) induces the high levels of transcription in reporter assays (Ueda, 2002). A critical SP1 binding site is contained in the region from -80 to -20 and is essenti...

In [12] Quackenbush has expected that there should be subdirectly irreducible Steiner quasigroups (squags), whose proper homomorphic images are entropic (medial). The smallest interesting cardinality for such squags is 21. Using the tripling construction given in [1] we construct all possible nonsimple subdirectly irreducible squags of cardinality 21 (SQ(21)s). Consequently, we may say that the...

BACKGROUND Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the Central Nervous System that is immunologically mediated in genetically susceptible individuals. IL-21, a cytokine produced by TCD4(+) cells, particularly by Th-17 cells, is believed to play an important role in the MS pathogenesis. OBJECTIVE This study was performed to investigate the impact of genetic p...