نتایج جستجو برای: myopathies
تعداد نتایج: 2714 فیلتر نتایج به سال:
Statins are an extensively used class of drugs, and myopathy is an uncommon, but well-described side effect of statin therapy. Inflammatory myopathies, including polymyositis, dermatomyositis, and necrotizing autoimmune myopathy, are even more rare, but debilitating, side effects of statin therapy that are characterized by the persistence of symptoms even after discontinuation of the drug. It i...
Mutations of the gene encoding four-and-a-half LIM domain 1 (FHL1) are the causative factor of several X-linked hereditary myopathies that are collectively termed FHL1-related myopathies. These disorders are characterized by severe muscle dysfunction and damage. Here, we have shown that patients with idiopathic inflammatory myopathies (IIMs) develop autoimmunity to FHL1, which is a muscle-speci...
Lindqvist, J. 2014. Cellular and Molecular Mechanisms Underlying Congenital Myopathy-related Weakness. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 977. 45 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-8894-9. Congenital myopathies are a rare and heterogeneous group of diseases. They are primarily characterised by skeletal muscle weakness ...
Statins are considered to be safe, well tolerated and the most efficient drugs for the treatment of hypercholesterolemia, one of the main risk factor for atherosclerosis, and therefore they are frequently prescribed medications. The most severe adverse effect of statins is myotoxicity, in the form of myopathy, myalgia, myositis or rhabdomyolysis. Clinical trials commonly define statin toxicity ...
Autoimmune myopathies are complex groups of diseases arising from insult to one or more muscle groups. These characterized by symmetric
PURPOSE OF REVIEW Drug-induced muscle disorders are important causes of morbidity, but the risk-benefit profile of the incriminated drugs must be put into perspective. This review highlights some recent advances on statin-induced and antiretroviral drug-induced myopathies and calls attention to some less familiar myotoxic disorders. RECENT FINDINGS In statin myopathy, reduction of coenzyme Q ...
The most common drugs currently in use that may cause myopathies were reviewed using the Medline database (U.S. National Library of Medicine, Bethesda, Maryland). Our review included results from epidemiologic and database surveys, clinical trials, and case reports. The clinical spectrum is wide, and presentations range from asymptomatic elevations in serum creatine phosphokinase levels to seve...
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