نتایج جستجو برای: myofibroblasts

تعداد نتایج: 4109  

Journal: :American journal of translational research 2017
Xiaobin Guo Fangying Yan Jingyuan Li Chunmei Zhang Peili Bu

Cardiac fibrosis is a maladaptive response to various stresses, characterized by increased interstitial collagen deposition and progressive cardiac dysfunction. The transdifferentiation of fibroblasts into myofibroblasts is an essential process in the pathogenesis of cardiac fibrosis. SIRT3, as a mitochondrial NAD+-dependent histone deacetylase, has been demonstrated beneficial in many cardiova...

2016
Shuang Wang Xiao-Ming Meng Yee-Yung Ng Frank Y. Ma Shuang Zhou Yang Zhang Chen Yang Xiao-Ru Huang Jun Xiao Ying-Ying Wang Shuk-Man Ka Yong-Jiang Tang Arthur C.K. Chung Ka-Fai To David J. Nikolic-Paterson Hui-Yao Lan

Myofibroblasts are a main cell-type of collagen-producing cells during tissue fibrosis, but their origins remains controversial. While bone marrow-derived myofibroblasts in renal fibrosis has been reported, the cell origin and mechanisms regulating their transition into myofibroblasts remain undefined. In the present study, cell lineage tracing studies by adoptive transfer of GFP+ or dye-labell...

Journal: :American journal of physiology. Cell physiology 2009
S Samuel R Walsh J Webb A Robins C Potten Y R Mahida

Colonic epithelial stem cells are believed to be located at the crypt base where they have previously been shown to express musashi-1. The colonic stem cell niche, which includes extracellular matrix and myofibroblasts (together with other cell types), is likely to be important in maintaining the function of the progenitor cells. The aims of our studies were to characterize stem cells in isolat...

1999
C. Oliver M. J. Montes J. A. Galindo C. Ruiz E. G. Olivares

Previous reports in human and mouse material demonstrated that decidual stromal cells expressed antigens associated with haematopoietic cells, exerted immune functions, and originated from bone marrow. These findings suggested that these cells belonged to the haematopoietic lineage. We purified and expanded in culture precursors of human decidual stromal cells, and found in electron microscopic...

Journal: :The Journal of Cell Biology 2002
Jo Ellen Feugate QiJing Li Lina Wong Manuela Martins-Green

Chemokines are small cytokines primarily known for their roles in inflammation. More recently, however, they have been implicated in processes involved in development of the granulation tissue of wounds, but little is known about their functions during this process. Fibroblasts play key roles in this phase of healing: some fibroblasts differentiate into myofibroblasts, alpha-smooth muscle actin...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2001
A Orimo Y Tomioka Y Shimizu M Sato S Oigawa K Kamata Y Nogi S Inoue M Takahashi T Hata M Muramatsu

Myofibroblastic invasion associated with malignant epithelial cells of endometrial cancer as well as other cancers is often found in the interstitium. To assess the myofibroblastic-epithelial interaction, frozen sections from a total of 10 endometrial cancers with or without invasive myofibroblasts were immunohistochemically examined. Interestingly, the invasive myofibroblasts adjacent to malig...

2016
Shuang Liang Tatiana Kisseleva David A. Brenner

Chronic liver injury, resulted from different etiologies (e.g., virus infection, alcohol abuse, nonalcoholic steatohepatitis (NASH) and cholestasis) can lead to liver fibrosis characterized by the excess accumulation of extracellular matrix (ECM) proteins (e.g., type I collagen). Hepatic myofibroblasts that are activated upon liver injury are the key producers of ECM proteins, contributing to b...

2018
Minxiao Yi Bo Liu Yang Tang Fang Li Wan Qin Xianglin Yuan

Radiation induced pulmonary fibrosis (RIPF) is one of the major side effects of radiotherapy for lung cancer. Previous studies have shown that endothelial cells and activated myofibroblasts play a key role in RIPF. However, the interaction between irradiated endothelial cells and activation of myofibroblasts has not been reported. The aim of the present study was to examine whether irradiated e...

Journal: :Circulation research 2007
Michele Miragoli Nicolò Salvarani Stephan Rohr

Focal ectopic activity in cardiac tissue is a key factor in the initiation and perpetuation of tachyarrhythmias. Because myofibroblasts as present in fibrotic remodeled myocardia and infarct scars depolarize cardiomyocytes by heterocellular electrotonic interactions via gap junctions in vitro, we investigated using strands of cultured ventricular cardiomyocytes coated with myofibroblasts, wheth...

Journal: :Investigative ophthalmology & visual science 2012
James V Jester Donald Brown Aglaia Pappa Vasilis Vasiliou

PURPOSE The purpose of this study was to determine whether myofibroblast differentiation altered keratocyte crystallin protein concentration and increased cellular light scattering. METHODS Serum-free cultured rabbit corneal keratocytes and TGFβ (5 ng/mL) induced myofibroblasts were harvested and counted and protein/RNA extracted. Expression of myofibroblast and keratocyte markers was determi...

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