The tumor microenvironment dynamically regulates the progression of cancer. In the breast, a unique component of the microenvironment is the myoepithelial cell. Normal myoepithelial cells act as "natural tumor suppressors"; however, more recent evidence suggests that these cells develop phenotypic changes, which may contribute to loss of tumor suppressor activity. We have shown that myoepitheli...

The tumor microenvironment dynamically regulates the progression of cancer. In the breast, a unique component of the microenvironment is the myoepithelial cell. Normal myoepithelial cells act as "natural tumor suppressors"; however, more recent evidence suggests that these cells develop phenotypic changes, which may contribute to loss of tumor suppressor activity. We have shown that myoepitheli...

Electron microscope observations on eccrine sweat glands have been carried out by many workers, namely on human eccrine swear glands by HIBBS (1958), IIJIMA (1959), CHRALES (1960), KUROSUMI et al. (1960), and MUNGER (1961) and on those of animals by KITAMURA (1958), MUNGER et al. (1961), ELLIS et al. (1961), MATSUZAWA et al. (1963), KUROSUMI et al. (1964) and TERZAKIS (1964). Already by means o...

In the mammary gland, cell-cell contacts influence epithelial morphogenesis during the formation of ducts and alveoli. Desmosomes are adhesive intercellular junctions that are widespread in epithelia and other tissues. Although the components of desmosomes have been characterised at the molecular level, their precise function in epithelial organisation and morphogenesis has not been determined....

Apocrine cystomatosis, also called epitrichial sweat gland is a non-neoplastic condition characterised by multiple dilated cysts of origin. Histopathologically, these comprise two layers cells: an inner layer glandular epithelial cells and outer myoepithelial cells. A case apocrine cystomatosis was admitted to local hospital. The microscopic investigation revealed that some enlarged show...

Malignant myoepithelioma (myoepithelial carcinoma) of the breast is extremely rare. A case is reported of a 46 year old female with clear cell mammary malignant myoepithelioma that, on histological examination, was glycogen abundant clear cell carcinoma. Immunohistochemically, the clear cells showed myoepithelial differentiation--that is, they were a smooth muscle actin and S100 protein positiv...

We compared 4 breast cylindromas with 50 dermal cylindromas and 8 adenoid cystic breast carcinomas. Except for a modest increase in the number of eccrine ducts and reactive Langerhans cells in dermal cylindromas, breast and dermal cylindromas showed identical histologic and immunohistochemical features. Both were characterized by epithelial islands containing central basaloid cells and peripher...

The present report describes a rare case of spontaneous tumor of the salivary gland in a male Sprague-Dawley rat. The clinically confirmed mass rapidly developed in the cervical region between 19 and 21 weeks of age, and the animal was subsequently euthanized. At necropsy, a well-circumscribed nodule approximately 7 × 6 cm in diameter was found at the site of the salivary gland. The cut surface...