Background—Characterization of myocardial structural changes in heart failure (HF) with

Article history: Received 8 December 2016 Accepted 31 March 2017 Available online 13 April 2017 6 months. Thrombophilia workup revealed a homozygous MTHFR mutation for C677T gene. Nine months after the event, he had a repeat CT angiogram which showed resolution of the filling defect in his LAD and, repeat MRI which showed no wall motion abnormalities (even in the region of scar) and preserved L...

Hemorrhagic shock causes myocardial contractile depression. Although this myocardial disorder is associated with increased expression of tumor necrosis factor-alpha (TNF-alpha), the role of TNF-alpha as a myocardial depressant factor in hemorrhagic shock remains to be determined. Moreover, it is unclear which TNF-alpha receptor mediates the myocardial depressive effects of TNF-alpha. Toll-like ...

Management of the coronary circulation during cardiopulmonary bypass has remained a controversial issue for many years. A variety of perfusion techniques have been developed to protect the myocardium from ischemia and at the same time provide easy access to pathologic lesions requiring surgical intervention. Included in these techniques are total body hypothermia, normothermic ischemic arrest, ...

Kinins exert cardioprotective effects via 2 G-protein-coupled receptors, B1 and B2. Using B1 kinin receptor gene knockout mice (B1-/-), we tested the hypotheses that the B1 receptor plays an important role in preservation of cardiac function, whereas lack of B1 may accelerate cardiac remodeling and dysfunction after myocardial infarction, and that B2 receptors may compensate for lack of B1, whe...

Since the widespread use of hypothermic potassium cardioplegia began, marked reductions in perioperative mortality and the rate of Q wave-associated myocardial infarctions have been noted. No study to date has evaluated whether there has been an equally dramatic improvement in the incidence of postoperative myocardial infarctions unassociated with Q wave development. We used a previously valida...

OBJECTIVE To evaluate myocardial necrosis extent after myocardial infarction (MI) and reperfusion with primary coronary angioplasty in nondiabetic patients and the relationship with unstable preinfarction angina (PA). DESIGN Prospective cohort study. SETTING Studies suggest PA limits infarct size. This effect is questioned in patients treated with primary coronary angioplasty. PATIENTS Se...

Cellular therapy for myocardial injury has improved ventricular function in both animal and clinical studies, though the mechanism of benefit is unclear. This study was undertaken to examine the effects of cellular injection after infarction on myocardial elasticity. Coronary artery ligation of Lewis rats was followed by direct injection of human mesenchymal stem cells (MSCs) into the acutely i...