Introduction: First-pass perfusion MRI is a promising technique for detecting ischemic heart disease. However, the diagnostic value of the method is limited by the low spatial coverage, resolution, SNR, and cardiac motion related image artifacts. Parallel imaging methods have been applied in myocardial perfusion MRI, but the spatial coverage and SNR remain limited. Time-resolved data acquisitio...

Objective: To test the hypothesis that scintigraphic regional myocardial perfusion defects during exercise in patients with normal coronary angiography may be related to abnormal endothelium dependent vasoreactivity of the corresponding myocardial territory in response to cold pressor testing. Methods: 38 patients were classified into two groups according to the presence or absence of exercise ...

Myocardial perfusion SPECT imaging accounts for well over 90% of all myocardial perfusion imaging performed in the United States today. Although clearly superior to the traditional planar technique in terms of image contrast and consequent diagnostic and prognostic yield, the SPECT approach also involves additional acquisition and processing steps. This article concisely describes the entire te...

Methods 27 subjects (17 male; age 62 ± 11 years) with coronary artery disease as defined by quantitative coronary angiography were included in this study. Greater than 70% luminal coronary stenosis of the major epicardial coronaries was present in 2/3 of the subjects. Perfusion imaging was performed using a saturation recovery steadystate free precession dual-sequence method at 1.5 T during Reg...

PURPOSE To investigate the performance of the recently introduced spatiotemporal parallel imaging technique called parallel MRI with extended and averaged generalized autocalibrating partially parallel acquisitions (GRAPPA) kernels (PEAK-GRAPPA) for myocardial perfusion measurements. MATERIALS AND METHODS A study with 11 patients with myocardial infarction was performed to compare nonaccelera...

this study evaluated the relationship between the location of the most severe coronary artery stenosis and the subsequent acute myocardial infarction (ami). methods: of 1590 patients who were admitted with a diagnosis of ami, we identified 44 patients who had undergone previous myocardial perfusion spect. thirty-one of these patients also had previous coronary angiography. the relationship betw...

UNLABELLED Although human interpretation of (99m)Tc-sestamibi SPECT myocardial perfusion imaging has been repeatedly validated in the diagnostic and prognostic assessment of coronary artery disease, it remains unclear if automated computer-derived quantitative indices of perfusion have similar or independent prognostic information. METHODS We studied 718 patients referred for (99m)Tc-sestamib...

UNLABELLED To validate routine, noninvasive determination of absolute myocardial perfusion and coronary flow reserve (CFR), cardiac PET was performed in animals using a simplified imaging protocol, high-dose dipyridamole and a simplified quantitative algorithm specific for 82Rb and 13N-ammonia. METHODS One hundred thirty-five PET scans were obtained in eight dogs after intravenous 13N-ammonia...

PURPOSE Myocardial perfusion is routinely measured by SPECT--this technique has a rather low spatial resolution but covers the whole myocardium and is equipped with efficient image analysis software. Cardiac MRI has higher spatial resolution than SPECT and excellent sequences for myocardial function and viability detection but the lack of easy-to-use methods of acquisition and post-processing o...