I nfarct size was central to the major thrust of cardiac research in the 1970s and as such occupied center stage as the culprit to be conquered by interventions designed to cardioprotect and limit myocardial damage (infarct size). Myocardial infarction, with its consequent necrosis, was the leading cause of death and came under intense attack with infarct size posing as the surrogate villain. I...

BACKGROUND The phenomenon of silent myocardial infarction is poorly understood. METHODS We aimed to evaluate the prevalence, extent, and independent predictors of silent myocardial infarction in 2 large independent cohorts of consecutive patients without a history of myocardial infarction referred for rest/stress myocardial perfusion single photon emission computed tomography. There were 1621...

Preliminary clinical and laboratory observations suggest that nifedipine might prevent progression of threatened myocardial infarction by reversing coronary spasm or might limit necrosis during the course of acute myocardial infarction. We screened 3143 patients with ischemic pain of greater than 45 min duration and randomly assigned 105 eligible patients with threatened myocardial infarction a...

OBJECTIVES The objective of this study was to investigate whether strain Doppler echocardiography performed immediately after revascularization by percutaneous coronary intervention could predict the extent of myocardial scar, determined by contrast-enhanced magnetic resonance imaging (MRI). BACKGROUND There is considerable variability in survival rate after percutaneous coronary intervention...

background: diabetes mellitus is a strong risk factor for cardiovascular disease, including acute myocardial infarction (ami). management of risk factors and the other prevention services in recent years lead to a significant decrease in ami incidence. however, to examine the success of those strategies to control diabetes, this study aimed to identify the trends in prevalence of diabetes melli...

results prediction of the rca as culprit lesion using tierala's algorithm was 86% sensitive and 50% specific. prediction of lcx occlusion based on st-elevation ≥ 1 mm in v6 was 87% specific (p = 0.005). sum of st elevation in leads v5 and v6 more than 2.5 mm, was a good marker of lcx prediction (p = 0.044). st-elevation in v4r was 48% sensitive and 89% specific for rca prediction (p = 0.004). w...

background: cardiovascular disease is the main reason for mortality in men and women. clinical epidemiology of myocardial infarction (mi) in men and women has not been yet studied in iran, one of the largest middle east countries in south‑western asia. this study was conducted to determine the clinical epidemiology of mi in men and women in iran. methods: this hospital‑based, cross‑sectional st...

this study sought to compare the clinical features and outcome of a first acute myocardial infarction (ami) with onset of symptoms during or within 30 minutes of exercise, at rest and in bed. information collected using a standard questionnaire was used to relate activity at the onset of symptoms and in-hospital outcome in 500 consecutive patients admitted to our heart center with a first ami b...

Until recently, the use of nitroglycerin in patients with acute myocardial infarction has been contraindicated primarily because of possible hypotension or tachycardia which, with sublingual or oral preparations, would be difficult to control. The introduction of intravenous nitroglycerin and its use during experimentally induced infarction paved the way for its use in patients with acute myoca...

Both the incidence of acute ST-segment–elevation myocardial infarction (STEMI) and the mortality from STEMI have decreased over the last 3 decades. However, despite the success of reperfusion therapy by primary percutaneous coronary intervention (PCI) or thrombolysis, STEMI is still of significant concern. Although door-to-balloon time for primary PCI has declined, mortality has not, possibly b...