Acute myeloid leukemia is not a single disease but a group of neoplastic disorders. The malignant cells gradually replace, and inhibit the growth and maturation of, normal erythroid, myeloid, and megakaryocytic precursors. Included among the names for this condition are acute myelogenous leukemia, acute myelocytic leukemia, acute myeloid leukemia, acute myeloblastic leukemia, acute granulocytic...

In patients with acute myeloblastic leukaemia the mean serum ferritin concentration showed a twenty-five-fold increase compared with normal people, and in children with acute lymphoblastic leukaemia (A.L.L.) there was a thirteen-fold increase. The high concentration of circulating ferritin seemed to be related to increased synthesis by leukaemic cells. The return of serum concentrations to norm...

Background Hematopoietic stem cell (HSC) transplantation is the only treatment providing long-term cure in acute myeloblastic leukemia. At the apex of the hematopoietic system, quiescent HSCs escape to chemotherapeutic treatments and therefore can regenerate the entire blood system after drug exposure. Nevertheless, the consequence of repeated chemotherapy regimen on HSC function remains to be ...

Pyrimethamine, a substituted pyrimidine trations of pyrimethamine were 10-25% with potent folate antagonistic properof the simultaneous plasma concentraties, was given orally to treat two epitions. Considerations regarding lipid solsodes of meningeal leukemia in a longubility, body distribution, and easily term survivor with acute myeloblastic reversible toxicity of pyrimethamine sugleukemia. R...

Acute myeloblastic leukemia (AML) is a highly fatal malignant bone marrow disease. Physicians, dentists and all other healthcare professionals should be aware of sinister oral signs and symptoms in order to early diagnosis and referral of patients. Here we report a case of AML who presented with oral ulcers. Ulcers developed after a parrot bite, which initially misled the physicians. Unfortunat...

Frequency of additional chromosomal abnormalities in chronic myeloid leukemia (CML) is estimated to be 7% in chronic phase and increases to 40-70% in advanced disease. Progression of CML from chronic phase to accelerated phase or blast crisis is often associated with secondary chromosomal aberrations. We report an exceptional case of CML as debut in lymphoblastic blast crisis and a subsequent p...

Three patients with aplastic anaemia following chloroquine therapy are described. In two, chloroquine had been administered in large doses over a long period. One of them subsequently developed acute myeloblastic leukaemia. The third received only a small dose and pancytopenia with aplasia followed three weeks after ingestion of the drug. The mechanism(s) of chloroquine-induced marrow injury is...

Avian myeloblastosis virus produced in vitro by myeloblastic cells in suspension was labeled with 32P and 14Camino acids. After partial purification of the virus, and pronase digestion, an RNA was extracted by phenol into the aqueous phase. Glycerol gradient centrifugation showed that the 32P-labeled RNA con tained 2 distinct components: a high molecular weight fraction sedimenting at about 67 ...

Ribosomes were isolated and ribosomal RNA (rRNA) was prepared from leukemic cells derived from the venous blood of patients with acute myeloblastic leukemia, acute undifferentiated leukemia, subacute myelocytic leukemia, chronic lymphocytic leukemia, leukemic lymphosarcoma, leukemic reticuloendotheliosis, a cultured Burkitt lymphoma cell line, and phytohemagglutinin-stimulated normal lymphocyte...