نتایج جستجو برای: myelin repair
تعداد نتایج: 149331 فیلتر نتایج به سال:
Cockayne syndrome (CS) is a rare autosomal recessive neurodegenerative disease that is associated with mutations in either of two transcription-coupled DNA repair genes, CSA or CSB. Mice with a targeted mutation in the Csb gene (Cs-b(m/m)) exhibit a milder phenotype compared with human patients with mutations in the orthologous CSB gene. Mice mutated in Csb were crossed with mice lacking Xpc (X...
Background and purpose: Piperine as the main alkaloid of black pepper has antioxidant and neuroprotective properties, so, it is an appropriate candidate to be studied in animal models of multiple sclerosis. This research aimed at investigating the effect of pretreatment with piperine on spatial memory, oxidative stress, and myelin repair gene markers in local demyelination model. Materials and...
Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS.
The progressive loss of CNS myelin in patients with multiple sclerosis (MS) has been proposed to result from the combined effects of damage to oligodendrocytes and failure of remyelination. A common feature of demyelinated lesions is the presence of oligodendrocyte precursors (OLPs) blocked at a premyelinating stage. However, the mechanistic basis for inhibition of myelin repair is incompletely...
The present study investigated the effects of transforming growth factor (TGF)-β3 on the regeneration of facial nerves in rabbits. A total of 20 adult rabbits were randomly divided into three equal groups: Normal control (n=10), surgical control (n=10) and TGF-β3 treatment (n=10). The total number and diameter of the regenerated nerve fibers was significantly increased in the TGF-β3 treatment g...
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