SUMMARY The current study aims to use an oral lipophilic prodrug approach to promote the delivery of a model immunomodulator, mycophenolic acid (MPA) to the lymphatic system to facilitate enhanced uptake into lymphocytes. The project builds on recent studies demonstrating that targeted drug delivery to lymphocytes in the lymphatics may enhance immunomodulatory effects [1,2]. Two types of lipoph...

Partial amino acid deprivation of Bacillus subtilis, which evokes the stringent response, initiates sporulation not because the highly phosphorylated guanine nucleotides guanosine-5'-diphosphate-3'-diphosphate (ppGpp) and guanosine-5'-triphosphate-3'-diphosphate (pppGpp) increase but because GTP decreases. This was shown with a mutant (Myc) partially resistant to mycophenolate, an inhibitor of ...

Purpose To report long-term follow-up of a case of paraneoplastic optic neuropathy (PON) successfully treated with combination therapy. Observations We present a confirmed case of PON from cutaneous melanoma with nearly six years of meticulous follow-up in which vision was preserved and disease remission was successfully induced with combination mycophenolate mofetil, prednisone, and plasmaph...

TOPIC: Imaging TYPE: Medical Student/Resident Case Reports INTRODUCTION: Pulmonary nodules are common and usually found incidentally in about 20-50 % Chest Computed Tomography (CT) scans screening trials.[1] Evaluation of is necessary as differential broad includes malignancy, infectious diseases like tuberculosis (TB), hamartomas, sarcoidosis, wegner's granulomatosis, granulomas.[2] There have...

BACKGROUND The benefit of conversion from mycophenolate mofetil (MMF) to enteric-coated mycophenolate sodium (EC-MPS) in terms of gastrointestinal symptom burden has been evaluated previously using patient-reported outcomes. However, data are lacking concerning the sustained effect of conversion over time, and the potential impact of concomitant calcineurin inhibitor. METHODS In this 3-month,...