Binding of tris(phenanthroline)ruthenium(II), R~(phen),~+, enantiomers to nucleic acids of different base compositions and structure was examined by equilibrium dialysis and photophysical methods. Measurement of enantioselectivity combined with photophysical experiments permits the structural characterization of two noncovalent binding modes of the ruthenium(I1) complexes to the DNA helix, one ...

The pollution of surface water by recently used pesticides in Mekong Delta, a main drinking water source, is increasing both on the concentration residues and the polluted area [1,2]. Nanofiltration (NF) is arising as the most appropriate method for removal of pesticides with not only a good efficiency but also low energy consumption in comparison with other pressure-driven membrane processes [...

R-Synuclein (RSyn) is a small cytosolic protein of unknown function, which is highly enriched in the brain. It is genetically linked to Parkinson’s disease (PD) in that missense mutations or multiplication of the gene encoding RSyn causes early onset familial PD. Furthermore, the neuropathological hallmarks of both sporadic and familial PD, Lewy bodies and Lewy neurites, contain insoluble aggre...

Peritubular dentin (PTD) is a hypermineralized phase within the dentinal tubules in some vertebrate teeth as an interface between the intertubular dentin (ITD) and the cell processes. Our aim has been to understand the composition, structure and role of PTD as a mineralized tissue. We have utilized the technique of time of flight secondary ion mass spectrometry (TOF-SIMS) to map the distributio...

The lysine methyltransferase (KMT) SETMAR is implicated in response to and repair of DNA damage but its molecular function is not clear. More broadly, enzyme/substrate relationships are largely unknown for the dozens of predicted KMTs and hundreds or thousands of proteins modified by lysine methylation. SETMAR has been associated with di-methylation of histone H3 lysine 36 (H3K36) at sites of D...

An increase in United States water pollution has been denoted over the past 30 years. With a rise in water pollution, enhanced filtration and heavy metal remediation methods are imperative. Membrane fouling, the process whereby extraneous particles deposit onto a membrane surface and degrade the membrane’s performance, is a major issue facing ultrafiltration. This study’s goals were to enhance ...

The effect of the core substituent structure on the micellar behavior of thermoresponsive amphiphilic poly(εcaprolactone) diblock copolymer micelles was investigated through a combination of experimental and computational methods. The polycaprolactone (PCL) amphiphilic block copolymers used in this study consisted of a hydrophilic poly{γ-2-[2-(2-methoxyethoxy)ethoxy]ethoxy-ε-caprolactone} block...

The proteasome inhibitor Bortezomib is effective in hematologic malignancies such as multiple myeloma but has little activity against solid tumors, act covalently and is associated with undesired side effects. Therefore, non-covalent inhibitors that are less toxic and more effective against solid tumors are desirable. Structure activity relationship studies led to the discovery of PI-1840, a po...

Heme-derived linear tetrapyrroles (phytobilins) in phycobiliproteins and phytochromes perform critical light-harvesting and light-sensing roles in oxygenic photosynthetic organisms. A key enzyme in their biogenesis, phycocyanobilin:ferredoxin oxidoreductase (PcyA), catalyzes the overall four-electron reduction of biliverdin IXR to phycocyanobilin;the common chromophore precursor for both classe...

We report on the strong segregation of core− shell Au nanoparticles, with a shell layer consisting of a random copolymer brush of styrene and vinylphenol (PS-rPVPh-SH), in poly(styrene-b-2-vinylpyridine) (PS-b-P2VP) diblock copolymer. Because of the formation of multiple hydrogen bonds between the hydroxyl groups within the shell of the nanoparticles and the pyridine group in PS-b-P2VP, the Au ...